We describe the case of a 14-year-old Caucasian male, a resident in the Democratic Republic of the Congo, who was observed in Portugal with severe Plasmodium falciparum malaria with high-level parasitemia and severe thrombocytopenia. The course was complicated by bilateral sixth cranial nerve palsy during acute malaria, followed by the appearance of delayed cerebellar ataxia during the recovery...

Nitric oxide (NO) is thought to be an important mediator and critical signaling molecule for malaria immunopathology; it is also a target for therapy and for vaccine. Inducible nitric oxide synthase (iNOS) is synthesized by a number of cell types under inflammatory conditions. The most relevant known triggers for its expression are endotoxins and cytokines. To date, there have been conflicting ...

BACKGROUND Severe falciparum malaria may be complicated by prolonged haemolysis and recurrent fever after parasite clearance. However, their respective etiologies are unclear and challenging to diagnose. We report the first case of severe falciparum malaria followed by prolonged haemolytic anaemia and rhinomaxillary mucormycosis in a previously healthy adult male. CASE PRESENTATION A 30-year ...

introduction malaria is the most important parasitic infection, which is now spread all over the globe. malaria infections with more than two species, especially plasmodium falciparum and p. vivax, are common, but infections with p. malariae and p. falciparum are rare. discussion mixed malaria infection is not uncommon, and it needs to be diagnosed and treated effectively in order to control th...

Introduction Malaria remains a widespread health problem with huge burden. Severe or complicated malaria is highly lethal and encompasses variety of pathological processes, including immune activation, inflammation, dysmetabolism. Previously, we showed that adrenal hormones, in particular glucocorticoids (GCs), play critical roles to maintain disease tolerance during Plasmodium infection mice. ...

BACKGROUND AND PURPOSE Malaria had been eradicated in Taiwan since 1965, but there are currently 30 to 50 imported cases annually. The management of imported malaria continues to be challenging due to evolving drug resistance of Plasmodium parasites. METHODS We retrospectively analyzed the clinical presentations, treatment, and outcomes of all 16 adult patients (17 episodes) with imported mal...

it has been estimated that nearly half of the world’s population is at the risk of contracting malaria with sub saharan africa being the most risky area. the existing frontline malaria control interventions are not only expensive but also become ineffective owing to the emergence of insecticide and drug resistance. it calls for an innovative approach in terms of potential and reliable vaccine a...

1. Chen QY, Lan Ms, she JX, Maclaren NK. the gene responsible for autoimmune polyglandular syndrome type 1 maps to chromosome 21q22.3 in us patients. J Autoimmun 1998;11:177-183. 2. Halonen M, Eskelin P, Myhre Ag, et al. AIRE mutation and human leukocyte antigen genotypes as determinants of the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy phenotype. J Clin Endocrinol Metab 199...

OBJECTIVE Chhattisgarh in India is a malaria-endemic state with seven southern districts that contributes approximately 50-60% of the reported malaria cases in the state every year. The problem is further complicated due to asymptomatic malaria cases which are largely responsible for persistent transmission. This study was undertaken in one of the forested villages of the Keshkal subdistrict in...

CONTEXT Controversies in malaria prevention arise from the absence of data, conflicting data between different studies, conflicting recommendations, deviation of local practice from scientific data, and varying risk thresholds. Misconceptions about the seriousness of malaria, the tolerability of chemoprophylaxis drugs, and the efficacy and safety of repellents contribute to the controversies. ...