Platelet survival time was measured (autologous labelling with 51chromium) in 68 men with coronary artery disease (CAD). Survival was shortened slightly (3.2 ± 0.04 days; mean ± SEM) as compared to normal (3.7 ± 0.04 days; N = 18; P < 0.001), and 60% had shortened survival (< 3.3 days). Thirty-seven had hyperlipoproteinemia (36 with Type IV and one with Type III) and platelet survival was short...

Os agonista dos PPARs lesam o Complexo I da cadeia de elétrons mitocondrial a NADH citocromo-c redutase provocando aumento da geração de radicais livres de oxigênio, lesão do DNAmt e diminuição da produção de ATP mitocondrial o que desvia o metabolismo para glicólise anaeróbia, motor da proliferação celular maligna. Este efeito de lesão do Complexo I é leve com os fibratos – agonistas alfa (clo...

The combined oral administration of neomycin (2 g daily) and clofibrate (2 g daily) reduced significantly serum cholesterol levels in 15 of 16 patients. Most of these patients had type II hypercholesterolemia and clinical evidence of arteriosclerosis. The combined regimen of the two drugs was more effective in reducing cholesterol levels in about one third of the patients than administration of...