BACKGROUND The clinical significance of progesterone receptor (PgR) expression in estrogen receptor-negative (ER-) breast cancer is controversial. Herein, we systemically investigate the clinicopathologic features, molecular essence, and endocrine responsiveness of ER-/PgR+/HER2- phenotype. METHODS Four study cohorts were included. The first and second cohorts were from the Surveillance, Epid...

PURPOSE Invasive pleomorphic lobular carcinoma (IPLC) is a very rare and distinct morphological variant of invasive lobular carcinoma (ILC), characterized by nuclear atypia and pleomorphism contrasted with the cytologic uniformity of ILC. This study evaluated clinicopathologic characteristics and prognosis of IPLC compared with invasive ductal carcinoma (IDC). METHODS We retrospectively revie...

We would like to congratulate Skinner and colleagues on their recent article, in which they perform a thorough statistical comparison of multiple uveal melanoma classification systems that are based on anatomic features, including the TNM staging system. Although the TNM system can work well as a prognostication tool in some cancer types, its prognostic value in uveal melanoma has been disappoi...

OBJECTIVES To evaluate the clinicopathologic correlation and prognostic value of HPV18 DNA viral load in patients with early-stage cervical neuroendocrine carcinoma (NECA). METHODS Formalin-fixed, paraffin- embedded tissue of cervical NECA patients with known HPV18 infection and clinicopathologic data including follow-up results were collected. The HPV18 DNA load was assessed with quantitativ...

We would like to congratulate Skinner and colleagues on their recent article, in which they perform a thorough statistical comparison of multiple uveal melanoma classification systems that are based on anatomic features, including the TNM staging system. Although the TNM system can work well as a prognostication tool in some cancer types, its prognostic value in uveal melanoma has been disappoi...

OBJECTIVES To assess the use of indwelling tracheoesophageal speaking valves in Chinese patients undergoing laryngectomy, to identify the clinicopathologic factors for favorable outcome, and to evaluate the factors that determine prosthesis lifetime. DESIGN Retrospective review. SETTING Tertiary care institution. PATIENTS Sixty consecutive patients with total laryngectomy were included. A...

We would like to congratulate Skinner and colleagues on their recent article, in which they perform a thorough statistical comparison of multiple uveal melanoma classification systems that are based on anatomic features, including the TNM staging system. Although the TNM system can work well as a prognostication tool in some cancer types, its prognostic value in uveal melanoma has been disappoi...

Pyogenic granuloma-like Kaposi sarcoma (PG-like KS) is a clinicopathologic variant of (KS), vascular tumor caused by human herpesvirus-8 (HHV-8). PG-like KS challenging entity to diagnose because its clinical and histological features encompass both pyogenic granuloma (PG) Distinction between the two entities clinically important as management different. patients requires evaluation their immun...