BACKGROUND AND OBJECTIVES Salmonella is an important food-borne pathogen responsible for disease in humans and animals. The aim of this study was to investigate the genetic relationship among third generation cephalosporin-resistant Salmonella enterica strains by Enterobacterial Repetitive Intergenic Consensus (ERIC)-PCR. METHODS The study included all Salmonella isolates obtained from clinic...

Cefuroxime sodium is a second-generation parentally administered cephalosporin, used in both human and veterinary medicine. In veterinary medicine, cefuroxime sodium, active on Streptococcus agalactiae, Streptococcus dysgalactiae, is administered intramammary for the treatment of mastitis in cattle during the lactating period. Cefquinome sulphate is a fifth generation cephalosporin, which is ad...

The susceptibility of 29 strains of Eikenella corrodens to penicillin, apalcillin, and 12 new cephalosporins was determined by the agar dilution method. Most strains were resistant to cefsulodin, and some were resistant to apalcillin and cefpiramide. Although all strains were susceptible to the other cephalosporins tested, most of those drugs were as active as or less active than penicillin. Su...

Emergence of methicillin-resistant Staphylococcus aureus (MRSA) has created challenges in treatment of nosocomial infections. The recent clinical emergence of vancomycin-resistant MRSA is a new disconcerting chapter in the evolution of these strains. S. aureus normally produces four PBPs, which are susceptible to modification by beta-lactam antibiotics, an event that leads to bacterial death. T...

The recent emergence of Neisseria gonorrhoeae strains with decreased susceptibility to extended-spectrum cephalosporins is a major concern globally. We sequenced the genome of an N. gonorrhoeae multiantigen sequence typing (NG-MAST) ST1407 isolate (SM-3) with decreased susceptibility and resistance to oral extended-spectrum cephalosporins. The isolate was cultured in 2008 in San Francisco, CA, ...

OBJECTIVE To review the evidence that supports the use of certain cephalosporins in penicillin-allergic patients. DATA SOURCES Published articles were identified through Medline and EMBASE (1960-2007) using the search terms penicillin and allergy and cephalosporin and cross-reactivity. Additional sources were identified from the authors' personal collection and the reference bibliographies. ...

Some cephalosporins, such as cefadroxil, are orally available. H(+)-coupled peptide transporter 1 mediates the transport of cephalosporins across the apical membrane of enterocytes. It is not known which mechanism(s) is responsible for the subsequent transport of cephalosporins across the basolateral membrane toward the circulation. We have tested whether ATP-binding cassette (ABC) transporters...