Candidiasis is a major health concern causing both morbidity and mortality. The increasing prevalence of antimicrobial-resistant fungi associated with life-threatening systemic mycoses, led constant need for new antifungal agents. Herbal medicines have been tried this purpose centuries. effect fig tree latex has reported some trace elements such as zinc were effects. aim study was to determine ...

A series of 4-thioflavonols compounds were synthesized by treating flavonols with lawsons reagent variable substituent groups at A, B, and AB rings. All the checked for antibacterial antifungal activity. We report that many found active against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Methicillin-resistant bacterial strains and, C. albicans, parapsilosisstrains krusei fu...

OBJECTIVE To evaluate CHROMagar Candida (CA), a new yeast differential medium, for yeast isolation in a clinical laboratory for the routine examination of high vaginal swabs. METHODS Results of high vaginal swab cultures processed in a standard manner on plates containing equal halves of Sabouraud dextrose agar (SDA) and CA were compared. Non-Candida albicans yeast isolates were further speci...

OBJECTIVE The aim of this investigation was to measure the postantifungal effect (PAFE) of 6 different oral Candida species following exposure to amphotericin B. MATERIALS AND METHODS Five oral isolates each of Candida albicans, Candida tropicalis, Candida krusei, Candida parapsilosis, Candida glabrata and Candida guilliermondii (total of 30 isolates) were examined for the presence of PAFE af...

Most Candida infections are related to microbial biofilms often formed by the association of different species. The objective of this study was to evaluate the interactions between Candida albicans and non-albicans species in biofilms formed in vitro. The non-albicans species studied were:Candida tropicalis, Candida glabrata and Candida krusei. Single and mixed biofilms (formed by clinical isol...

We compared the ability of the EUCAST EDef 7.2 and the Etest to detect the susceptibility to micafungin of 160 Candida and non-Candida clinical isolates. Agreement was higher when Etest MICs were obtained after 24 h of incubation; essential agreement was 90%, and categorical agreement was >90%. False susceptibility was seen only for Candida krusei (10%), and false resistance was observed in 6% ...

Invasive fungal infections are associated with very high mortality and morbidity. Candida sp. is a leading etiological cause of invasive fungal infections (IFI). The aim of this study was to investigate the epidemiology of FI in patients admitted to neonatal and paediatric ICU (NICU and PICU) to investigate risk factors that may contribute to FI development. In this retrospective epidemiologic ...

Western blotting was applied to the analysis of Candida albicans in the yeast and mycelial phases in an attempt to recognise mycelial specific antigens which might be of serodiagnostic value. The antisera were prepared in rabbits by immunising them with pressates of C albicans type A NCTC 3153 in the yeast phase or the mycelial phase. These were blotted against C albicans in the yeast and mycel...

Candida krusei is a diploid, heterozygous yeast that is an opportunistic fungal pathogen in immunocompromised patients. This species also is utilized for fermenting cocoa beans during chocolate production. One major concern in the clinical setting is the innate resistance of this species to the most commonly used antifungal drug fluconazole. Here, we report a high-quality genome sequence and as...