To elucidate the molecular mechanism underlying high metastasis rate of brain for non-small cell lung cancer patients and to establish a comprehensive differential gene profile metastasis. The differentially expressed genes were systematically investigated. enriched biological processes signaling pathways explored. protein-protein interaction network was constructed. Compared with primary cance...

We now define three new constructions. A set is down-closed if: (Def.1) for all a, b such that a ∈ it and b ⊆ a holds b ∈ it. A set is binary complete if: (Def.2) for every A such that A ⊆ it and for all a, b such that a ∈ A and b ∈ A holds a ∪ b ∈ it holds ⋃ A ∈ it. Let us observe that there exists a down-closed binary complete non-empty set. A coherent space is a down-closed binary complete n...

efg1 transcription factor is believed to be the main regulator of hyphal formation under many different conditions. in addition, it is responsible for positive regulation of the expression of several hyphal-specific genes. sap5, which encodes secreted aspartic proteinase, is one of the mentioned genes and is crucial for pathogenicity properties. in the present work we have established the exper...

The interaction of interleukin-2 (IL-2) with its receptor (IL-2R) decreases cytochrome P-450 (CYP) expression in rat hepatocytes. Because IL-2 increases c-Myc in lymphocytes and because c-myc overexpression represses several genes, we postulated that the IL-2/IL-2R interaction may increase c-Myc and thereby down-regulate CYP in hepatocytes. Cultured rat hepatocytes were exposed for 24 h to IL-2...

ATRA (all-trans retinoic acid), which is a major bioactive metabolite of vitamin A and a potent regulator of development and differentiation, mediates down-regulation of the human albumin gene. However, the mechanism of ATRA-mediated down-regulation is not well understood. In the present study, deletion analysis and luciferase assays demonstrate that ATRA causes a marked decrease in the activit...