CD4+CD25+FOXP3+ is a regulatory T cell that plays role in the body's tolerant system to control activated effector cells. an important as trigger for tumor progressiveness, where increase amount of FOXP3 state correlates with poor prognosis. Breast cancer type tends every year. The purpose this study was influence combination Phyllanthus urinaria and Catharanthus roseus plant extracts on modula...

Catharanthus roseus (L.) G. Don is a herbal plant traditionally used by local populations in India, South Africa, China and Malaysia to treat diabetes. The present study reports the in vitro antioxidant and antidiabetic activities of the major alkaloids isolated from Catharanthus roseus (L.) G. Don leaves extract. Four alkaloids--vindoline I, vindolidine II, vindolicine III and vindolinine IV--...

Rational engineering of complicated metabolic networks involved in the production of biologically active plant compounds has been greatly impeded by our poor understanding of the regulatory and metabolic pathways underlying the biosynthesis of these compounds. Whereas comprehensive genome-wide functional genomics approaches can be successfully applied to analyze a select number of model plants,...

Human activities like mining, transport, agriculture, industrial waste disposal and military actions release inorganic pollutants in high concentrations that are toxic to natural ecosystems. Heavy metal pollution causes potential ecological risk. Heavy metals like Cadmium (Cd), Lead (Pb) and Chromium (Cr) when present in high concentrations in soil exert potential toxic effects on overall growt...

Members of the Apocynaceae plant family produce a large number of monoterpenoid indole alkaloids (MIAs) with different substitution patterns that are responsible for their various biological activities. A novel N-methyltransferase involved in the vindoline pathway in Catharanthus roseus showing distinct similarity to γ-tocopherol C-methyltransferases was used in a bioinformatic screen of transc...

Mammalian tumour cells exhibit resistance to chemotherapy and its severe side effects reduces the clinical efficacy of a large variety of anticancer agents. Plant-derived compounds manifest many beneficial effects and can possibly inhibit several stages of cancer. Despite there is significant progress in cancer therapeutics in the last decades, the need to discover, develop new and synergistic ...

The present study establishes the analgesic and anti-pyretic activities of the ethanolic extract of leaves of Catharanthus roseus in the models used. Since antipyretic and analgesic activities are commonly mentioned as characteristic of drugs or compounds which have an inhibitory effect on prostaglandin biosynthesis, the yeast induced hyperthermia in rat model was, therefore, employed to invest...

Jasmonates are plant signalling molecules that play key roles in defence against insects and certain pathogens, among others by controlling the biosynthesis of protective secondary metabolites. In Catharanthus roseus, the AP2/ERF-domain transcription factor ORCA3 controls the jasmonate-responsive expression of several genes encoding enzymes involved in terpenoid indole alkaloid biosynthesis. OR...

Hancornia speciosa, popularly known as mangabeira, is a fruit tree native to the Brazilian Cerrado that shows great economic potential, due to its multiple uses. Intraspecific classification of this species is difficult because it shows high morphological diversity. An early study of the species reported that there are six botanic varieties that differ morphologically mainly in the shapes of th...