The cephalosporin group of antibiotics has gained widespread use in combating resistant infections. Because of the necessity for intravenous administration of cephalothin, and the intramuscular route for cephaloridine, the development of a new member of this series which is effective orally prompted study of its penetration into the eye. This is the first reported study of the passage of cephal...

The immediate effects of topical salbutamol, a beta 2 adrenergic agonist, on the aqueous humour dynamics of 22 normal subjects was studied by fluorophotometry and tonography. Significant lowering of intraocular pressure was accompanied by a significant increase in both aqueous flow rate and tonographic facility of outflow. Uveoscleral outflow was calculated and found to be significantly increas...

A new method of measuring aqueous humor flow and corneal endothelial permeability to fluorescein using a fluorophotometry nomogram is described. This method is compared to four other methods, two of which have been described previously. All five methods were carried out simultaneously in a group of 20 normal human subjects. All methods give closely comparable results in most of the eyes tested....

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Several parameters of aqueous humor dynamics were measured in 11 human subjects before and after exposure of one eye to a continuous stream of cold air. In the treated eye, I.O.P. was found to decrease significantly from a mean +/- SD pre-treatment value of 14.1 +/- 2.3 mmHg to a post-treatment value of 12.6 +/- 2.6 mmHg. Episcleral venous pressure was found to decrease significantly from a pre...

Although the levels of LDH have been estimated in the aqueous humour of animals (Kuhlman, and Kaufman, I960), information regarding LDH levels in human aqueous humour appears to be scanty. It is known that malignant tumours at different sites in the body are associated with an increased LDH activity in the corresponding body fluid (Wroblewski, 1957). The purpose of the present study is to deter...

The identification of a new class of potent and selective ROCK-II inhibitors is presented. Compound 5 (SR-3677) had an IC 50 of approximately 3 nM in enzyme and cell based assays and had an off-target hit rate of 1.4% against 353 kinases, and inhibited only 3 out of 70 nonkinase enzymes and receptors. Pharmacology studies showed that 5 was efficacious in both, increasing ex vivo aqueous humor o...

The induction of acute reversible lens opacities in the Stjrian hamster following phenylephrine mydriasis is accompanied by an increase in the sodium and potassium concentration and a decrease in the water content of the lens. There is a simultaneous increase in sodium concentration in the aqueous humor. Final analysis of the effect of various drugs on these lens opacities should reveal that th...

Richard F. Figure 1 shows a human eye without its aqueous circulation. The cornea is thickened, the anterior chamber is absent, the iris is partly atrophic, and the lens is cataractous. The picture serves as a reminder of the dependency of the health of the eye on the continuous supply of aqueous humor that circulates through its chambers. It is surprising that it was not known until recently t...

The rate of accumulation of C-labeled thiourea in the aqueous humor of the anterior and posterior chambers of rabbits has been studied. The coefficients of transport by flow and diffusion and the concentration in the "secreted fluid" have been evaluated and compared with corresponding values for urea. The remits demonstrate that thiourea penetrates both the iris and ciliary processes more rapid...