INTRODUCTION There are few studies from India documenting the adverse effects of generic HAART (Highly Active Anti-retroviral Therapy). METHODOLOGY A prospective study was conducted at Mysore, India, to study the adverse effects after HAART initiation in a cohort of 100 antiretroviral therapy (ART)-naive patients, who were evaluated prospectively every three months by clinical and laboratory ...

The reproductive toxicity of combined fixed-dose first-line antituberculosis (CFDAT) regimen was assessed in rats. Thirty-two (32) Wistar rats weighing 168.1 ± 8.0 g were divided into four groups of eight rats per group. Two groups of male and female rats were administered oral distilled water (1.6 ml) and CFDAT drugs containing rifampicin, isoniazid, pyrazinamide and ethambutol (RIPE, 92.5 mg/...

The altered response to antituberculous agents of both the tubercle bacilli cultured from the sputum and from excised pulmonary lesions during and after therapy with these drugs has aroused the interest of the bacteriologist, the pathologist and the clinician. Therefore, many studies of this problem based upon clinical material subjected to wide varieties of drug-treatment regimens have been re...