The antineoplastic platinum complexes cisplatin and its analogues are widely used in the chemotherapy of a variety of human malignancies, and are especially active against several types of cancers. Nedaplatin is a second-generation platinum complex with reduced nephrotoxicity. However, their use commonly causes nephrotoxicity due to a lack of tumor tissue selectivity. Several recent studies hav...

Drug-metabolizing enzymes and drug transporters are key determinants of the pharmacokinetics and pharmacodynamics of many antineoplastic agents. Metabolism and transport influence the cytotoxic effects of antineoplastic agents in target tumor cells and normal host tissues. This article summarizes several state-of-theart approaches to enhancing the effectiveness and safety of cancer therapy base...

Peripheral neurotoxicity is a dose-limiting and disabling side effect of several important chemotherapeutic agents. In particular, vincristine, cisplatin, oxaliplatin, paclitaxel, and docetaxel are frequently used antineoplastic agents, which are known causes of a peripheral neuropathy. The recently registered proteasome inhibitor bortezomib, which is effective in multiple myeloma, is the lates...

Peripheral neurotoxicity is a dose-limiting and disabling side effect of several important chemotherapeutic agents. In particular, vincristine, cisplatin, oxaliplatin, paclitaxel, and docetaxel are frequently used antineoplastic agents, which are known causes of a peripheral neuropathy. The recently registered proteasome inhibitor bortezomib, which is effective in multiple myeloma, is the lates...

Extracutaneous involvement in mycosis fungoides (MF) carries a poor prognosis. Oral and gastrointestinal (GI) tract lesions are both rare locations of disease. We describe the clinical findings of one case with oral and GI MF complicated by perforation after systemic antineoplastic treatment, and review the relevant literature. The patient had a 1-year history of MF before development of tongue...

Potential difference across the cell membrane and intracellular activity of the potassium ion in rat liver cells were measured simultaneously using double-barreled potassium ion-selective microelectrodes. Both potential difference across the membrane and K+ activity in liver cells were depressed after treatment with the antineoplastic agents mitomycin C and 5-Flourouracil Dry Syrup, suggesting ...

Background The induced differentiation of tumor cells represents a very important strategy in modern antineoplastic therapy. Retinoids are the most frequently used group of cell differentiation inducers; however, their toxicity and intrinsic or acquired resistance to retinoids substantially limit their use in clinical protocols. Therefore, special attention has been paid to the combined treatme...

Garlic has long been used medicinally, most recently for its cardiovascular, antineoplastic, and antimicrobial properties. Sulfur compounds, including allicin, appear to be the active components in the root bulb of the garlic plant. Studies show significant but modest lipid-lowering effects and antiplatelet activity. Significant blood pressure reduction is not consistently noted. There is some ...

This guideline provides an approach to the prevention of acute antineoplastic-induced nausea and vomiting (AINV) in children. It was developed by an international, inter-professional panel using AGREE and CAN-IMPLEMENT methods. Evidence-based interventions that provide optimal AINV control in children receiving antineoplastic agents of high, moderate, low, and minimal emetogenicity are recommen...

Patients with cancer have a high risk of deep vein thrombosis and pulmonary embolism, as well developing atrial fibrillation (AF) secondary to antineoplastic treatment. These events poor prognosis depend on factors related the tumor ongoing therapy. They are usually elevated during first 6 months […] How Anticoagulate Heart Failure Cancer?