Iguratimod is a new synthetic disease-modifying antirheumatic drug intended to treat patients with rheumatoid arthritis. A new method using recombinant human CYP450s yeast cells containing c-DNA expressed P450s was applied to identify the metabolic pathways of iguratimod and to prepare its metabolite. The metabolite was isolated, and its structure was identified by quadrupole time-of-flight-mas...

The phenazine-1-carboxamide-producing bacterium Pseudomonas chlororaphis PCL1391 controls tomato foot and root rot caused by Fusarium oxysporum f. sp. radicislycopersici. To test whether root colonization is required for biocontrol, mutants impaired in the known colonization traits motility, prototrophy for amino acids, or production of the site-specific recombinase, Sss/XerC were tested for th...

Burkholderia gladioli is a bacterium with broad ecology spanning disease in humans, animals and plants, but also encompassing multiple beneficial interactions. It plant pathogen, toxin-producing food-poisoning agent, causes lung infections people cystic fibrosis (CF). Contrasting traits include antifungal production exploited by insects to protect their eggs, protective abilities antibiotic bio...

Iguratimod is a new synthetic disease-modifying antirheumatic drug intended to treat patients with rheumatoid arthritis. A new method using recombinant human CYP450s yeast cells containing c-DNA expressed P450s was applied to identify the metabolic pathways of iguratimod and to prepare its metabolite. The metabolite was isolated, and its structure was identified by quadrupole time-of-flight-mas...

Background: To determine the atmospheric contamination by pesticides, conducting laboratory studies is necessary before operating field studies. The aim of this research study was to develop an analytical method to sample and simultaneously determine airborne amitraz and its metabolite. Methods: A modified fritted impinger with acetonitrile as the liquid sorbent was used in order to study the...

background: to determine the atmospheric contamination by pesticides, conducting laboratory studies is necessary before operating field studies. the aim of this research study was to develop an analytical method to sample and simultaneously determine airborne amitraz and its metabolite. methods: a modified fritted impinger with acetonitrile as the liquid sorbent was used in order to study the a...

an experiment was conducted in algerian desert goats to study the effect of age and season on blood biochemical and mineral profile during different physiological stages of the goats. serum ca, mg and na levels were significantly high at birth and decreases as the age advanced. the season had a significant effect on the decreased levels of ca, mg and k and inversely on the increased levels of n...

Tea tree oil (TTO), a volatile essential oil, has been widely used as an antimicrobial agent. However, the mechanism underlying TTO antifungal activity is not fully understood. In this study, a comprehensive metabolomics survey was undertaken to identify changes in metabolite production in Botrytis cinerea cells treated with TTO. Significant differences in 91 metabolites were observed, includin...