Objectives: Mentha longifolia L. (Lamiaceae) is an annual herb that is used in the Iranian traditional medicine for treating stomach and intestinal disorders. The purpose of this study was to determine the protective effect of M. longifolia on experimental diarrhea in a rat model. Materials and Methods: The antidiarrheal activity of essential oil of M. longifolia (20-80 mg/kg) was investigated ...

BACKGROUND Till now many of medicinal plants having claimed therapeutic value traditionally are waiting scientific verification of their efficacy and safety. Accordingly this study is conducted to evaluate the antidiarrheal activity of hydromethanolic root extract of Indigofera spicata Forssk. in castor oil induced diarrhea model, misoprostol induced secretion model and its antimotility activit...

BACKGROUND & AIMS Diosmectite is a clay used to treat children with acute watery diarrhea. However, its effects on stool output reduction, the key outcome for pediatric antidiarrheal drugs, have not been shown. METHODS Two parallel, double-blind studies of diosmectite efficacy on stool reduction were conducted in children 1 to 36 months old in Peru (n = 300) and Malaysia (n = 302). Inclusion ...

3 Wuster M, Herz A. Opiate agonist action of antidiarrhoeal agents in vitro and in vivo-findings in support for selective action. Naunyn Schmiedebergs Arch Pharmacol 1978;301:187-94. 4 Niemegeers CJE, McGuire JL, Heykants JJP, Janssen PAJ. Dissociation between opiate-like and antidiarrheal activities of antidiarrheal drugs. J Pharmacol Exp Ther 1979;210:327-33. 5 Van Nueten JM, Janssen PAJ, Fon...