background: sohan is an iranian traditional brittle confection which its ingredients are susceptible to oxidation and microbial contamination during storage. this experimental study was designed to determine the effect of damask rose (rosa damascena mill.) extract on some chemical, microbial, and sensory properties of sohan during storage at 25 °c. methods: the sohan ingredients were mixed, bak...

background: escherichia coli and staphylococcus aureus as important food-borne pathogens are the main concerns of food producers and consumers which create a lot of problems worldwide. the objective of this study was to investigate the inhibitory effect of monolaurin alone and in combination with edta on viability of e. coli and s. aureus in culture media and iranian white cheese. methods: the ...

background: the most frequently used spermicide nonoxynol-9 (n-9) in the clinic alters the vaginal flora, which will result in an increased risk of opportunistic infection. so development of a novel spermicidal and microbicidal drug appears to be inevitable. vaginal local immune is an important part of vaginal flora. secretory leukocyte protease inhibitor (slpi), surfactant proteins d (sp-d), a...

In the advent of an influenza virus pandemic it is likely that the administration of antiviral drugs will be an important first line of defence against the virus. The drugs currently in use are effective against seasonal influenza virus infection, and some cases have been used in the treatment of patients infected with the avian H5N1 influenza virus. However, it is becoming clear that the emerg...

We studied anti-influenza cytotoxicity by bulk peripheral blood mononuclear leukocyte (PBL) cultures derived from older, chronically ill volunteers undergoing vaccination. Vaccinees received either cold-recombinant, live-attenuated influenza A/Korea/1/82 (H3N2) virus intranasally or inactivated monovalent influenza A/Taiwan/1/86 (H1N1) subvirion vaccine intramuscularly. PBL were collected pre- ...

Viral neuraminidase inhibitors are widely used as synthetic anti-influenza drugs for the prevention and treatment of influenza. However, drug-resistant influenza A virus variants, including H5N1 highly pathogenic avian influenza viruses (HPAIVs), have been reported. Therefore, the discovery of novel and effective antiviral agents is warranted. We screened the antiviral effects of 11 herbal tea ...

Attenuated strains of invasive enteric bacteria, such as Salmonella, represent promising gene delivery agents for nucleic acid-based vaccines as they can be administrated orally. In this study, we constructed a novel attenuated strain of Salmonella for the delivery and expression of the hemagglutinin (HA) and neuraminidase (NA) of a highly pathogenic H5N1 influenza virus. We showed that the con...

Influenza A viral infections reached pandemic levels in 1918, 1957, 1968, and, most recently, in 2009 with the emergence of the swine-origin H1N1 influenza virus. The development of novel therapeutics or prophylactics for influenza virus infection is urgently needed. We examined the evaluation of the anti-influenza virus (A/WSN/33 (H1N1)) activity of Brazilian green propolis water extract (PWE)...

Ethanolic extracts of 20 medicinal plants were screened for influenza virus NA inhibition and in vitro antiviral activities using MDCK cells in an MTT assay. The vaccine proteins of influenza virus A/New Caledonia/20/99 (H1N1), mouse-adapted influenza virus A/Guizhou/54/89 (A/G)(H3N2) and mouse-adapted influenza virus B/Ibaraki/2/85 (B/I) were used in the NA inhibition assay, and mouse-adapted ...