Anaplastic large cell lymphoma (ALCL) exhibiting the t(2;5) translocation is characterized by the resulting expression of the oncogenic fusion protein nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) gene product. The ALK domain of NPM-ALK contains kinase activity, which is responsible for the autophosphorylation of tyrosine residues of the oncogenic protein and phosphorylation of SH2-protein...

Anaplastic large cell lymphoma (ALCL) is a non-Hodgkin's lymphoma that originates from T cells and frequently expresses oncogenic fusion proteins derived from chromosomal translocations or inversions of the anaplastic lymphoma kinase (ALK) gene. The proliferation and survival of ALCL cells are determined by the ALK activity. Here we show that the kinase activity of the nucleophosmin (NPM)-ALK f...

To the Editor: In non-small cell lung cancer (NSCLC), several driver oncogenes, including epidermal growth factor receptor (EGFR) and echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK), have been found. Th is has led to the development of personalized therapy with EGFRor ALKtyrosine kinase inhibitor (TKI); however, in clinical practice, oncologists’ percept...

Non-Hodgkin lymphoma (NHL) comprises of heterogeneous group lymphoid malignancies originating from lympho-reticular tissues and is quite uncommon in pregnancy (0.8 cases per 1,00,000 women). Anaplastic large cell (ALCL) a large-cell neoplasm with anaplastic morphology classified under NHL. Here, 31 year old primigravida diagnosed NHL ALCL subtype third trimester, started on chemotherapy which r...

Abstract: Introduction: Alectinib, an anaplastic lymphoma kinase inhibitor of BCS class IV, is said to have pH-dependent solubility and susceptible interactions with co-prescribed acid-reducing agents. Objectives: A micro-dissolution study was performed determine the effect modulations in gastrointestinal pH using biorelevant media a sensitive RP-HPLC technique developed for quantification alec...