Transport of proteins through the ALP (alkaline phosphatase) pathway to the vacuole requires the function of the AP-3 adaptor complex and Vps41p. However, unlike other adaptor protein-dependent pathways, the ALP pathway has not been shown to require additional accessory proteins or coat proteins, such as membrane recruitment factors or clathrin. Two independent genetic approaches have been used...

Breast cancer is the most common neoplasm affecting women in the western world with an average frequency of 1 in 11, developing the malignancy and it is second most common cancer in India. Variations in serum levels of biochemical parameters especially alkaline phosphatase (ALP) changes may be of great help in diagnosis of breast carcinoma. Serum ALP activity was assayed in 388 histopathologica...

BACKGROUND The prognostic value of serum alkaline phosphatase (S-ALP) has not been fully validated for nasopharyngeal carcinoma (NPC). MATERIALS AND METHODS S-ALP levels were measured in 601 patients newly diagnosed with NPC before radical treatment, and possible associations of these levels with 5-year overall survival (OS) and tumor-free survival (TFS) were explored using univariate and mul...

A one-step, single use, disposable Alkaline Phosphatase (ALP) biosensor has been developed. It is based on the detection of phenol produced by an ALP enzymatic reaction. It can operate at 25 °C in a pH 10 medium. It measures ALP of 0-300 IU/L. The permissible concentrations of glucose, ascorbic acid and urea without interference are 10 mM/L, 5 mg/L and 400 mg/L, respectively. Experimental resul...

The expression and property of alkaline phosphatase (ALP) in Eca109 cells, a cell line derived from human esophageal carcinoma were studied with specific inhibition assay and poly-acrylamide gel electrophoresis. The results showed that ALP of Eca109 cells was heat stable and was strongly inhibited by L-phenyalanine, but slightly inhibited by urea. Prednisolone could cause dramatic increase in a...

Alkaline phosphatase (ALP) flare phenomenon documented as scintigraphic flare phenomenon due to elevated serum ALP levels produced by osteoblasts reflects an osteoblastic reaction in response to the effective therapy of non-small cell lung cancer (NSCLC). Here, we report a case of ALP flare following gefitinib treatment for NSCLC. We also retrospectively analyzed the prevalence of ALP flare in ...

A light axionlike particle or an (ALP) not just gives rise to interesting and spectacular signals of new physics as final states in meson decays, it necessarily leaves tell-tale signatures processes that involve standard model (SM) fields only (i.e., SM processes). These effects result the violation Gell-Mann-Okubo mass relation, modified form factors, altered integrated differential rates for ...

A bstract high-energy muon collider with center-of-mass energy around and above 10 TeV is also a vector boson fusion (VBF) machine, due to the significant virtual electroweak (EW) gauge content of beams. This feature, together clean environment, makes it an ideal search for TeV-scale axion-like particles (ALP) coupling Standard Model EW bosons, which current other future colliders have limited ...