Growth of 7,12-dimethylbenz(alpha)anthracene-induced mammary carcinoma in rat was arrested by daily s.c. injections of cholera toxin. At a dose of 2 micrograms/200-g rat, tumors regressed to 50% of their initial size within 2 weeks, and 85% of tumors regressed completely within 4 to 5 weeks. The same response to cholera toxin was observed with another hormone-dependent mammary tumor, MTW9, but ...

In fat cells isolated from the parametrial adipose tissue of rats, the addition of purified adenosine deaminase increased lipolysis and cyclic adenosine 3’: 5’-monophosphate (cyclic AMP) accumulation. Adenosine deaminase markedly potentiated cyclic AMP accumulation due to norepinephrine. The increase in cyclic AMP due to adenosine deaminase was as rapid as that of theophylline with near maximal...

have been prepared and studied for possible incorporation into polynucleotides. Arab inosylcytosine mono-, di-, and triphosphates were synthesized by both chemical and enzymatic methods. Labeled and unlabeled arabinosylcytosine nucleotides were tested for their capacity to serve as substrates for purified polynucleotide phosphorylase, deoxyribonucleic acid-dependent ribonucleic acid polymerase,...

Significance We custom synthesize a fluorescent ligand and use highly sensitive microscopy methods to show that receptors may be targeted distinct sites of cell. provide microscopic images the localization ? 1 ?adrenergic (? -ARs) 2 ?ARs), main drivers contractility heart, in heart muscle cells. ?ARs are exclusively specific structures these cells, T-tubules, while -ARs found at entire cell sur...