نتایج جستجو برای: acute myelocytic leukemia
تعداد نتایج: 688188 فیلتر نتایج به سال:
BACKGROUND AND OBJECTIVES Methotrexate (MTX) is a key drug in the curative regimen of children with acute lymphocytic leukemia. This drug is widely used not only in the treatment of neoplastic diseases such as leukemia, lymphoma, choriocarcinoma, head and neck cancer and osteogenic sarcoma, but also for various autoimmune diseases, e.g., rheumatoid arthritis and psoriasis, and for the preventio...
The human t(3;21)(q26;q22) translocation is found as a secondary mutation in some cases of chronic myelogenous leukemia during the blast phase and in therapy-related myelodysplasia and acute myelogenous leukemia. One result of this translocation is a fusion between the AML1, MDS1, and EVI1 genes, which encodes a transcription factor of approximately 200 kDa. The role of the AML1/MDS1/EVI1 (AME)...
P ARAPROTEINS* ARE generally found in the serum in patients suffering from multiple myeloma or Waldenstr#{246}m’s macroglobulinemia. Recently, however, there have been a number of reports on patients in whom paraproteinemia#{176} was found in association with a myeloproliferative disorder such as polycythemia, erythroleukemia, acute myeloblastic and lymphoblastic leukemia, and chronic myelocyti...
Deoxycytidine kinase, which phosphorylates deoxycytidine (CdR) and its analog, cytosine arabinoside (ara-C), has been purified 71-fold from human leukemic cells. Biochemical properties of the partially purified enzyme included a molecular weight of 68,000, Kms of 7.8 muM for CdR and 25.6 muM for ara-C, and optimal activity with ATP and GTP as phosphate donors. Ara-C phosphorylation was strongly...
L YSOZYME, A CATIONIC POLYPEPTIDE of low molecular weight,’ is present in serum and in certain blood cells. The enzyme is found in granulocytes and monocytes but not in lymphocytes, red cells or platelets.23 Leukocyte lysozyme levels in general are increased in monocytic and decreased in lymphocytic leukemia.46 Varying levels have been reported in the myelocytic and monomyelocytic leukemias.4’T...
Vorinostat (suberoylanilide hydroxamic acid, SAHA) is a histone deacetylase inhibitor active clinically in cutaneous T-cell lymphoma and preclinically in leukemia. A phase 1 study was conducted to evaluate the safety and activity of oral vorinostat 100 to 300 mg twice or thrice daily for 14 days followed by 1-week rest. Patients with relapsed or refractory leukemias or myelodysplastic syndromes...
Tumor-specific antigens for leukemia cells have been sought for the past decades, but none of cell surface markers met sufficient criteria as a 'phenotypic signature'. Here we suggest that JL1 antigen can be efficiently used for diagnosis and treatment. JL1 is a human thymocyte differentiation antigen strictly confined to a CD4+CD8+ double positive subpopulation of cortical thymocytes. Despite ...
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