AK: actinic keratosis BCCs: basal cell carcinomas FD: field directed LD: lesion directed NMSC: nonmelanoma skin cancer OTRs: organ transplant recipients PDT: photodynamic therapy SCCs: squamous cell carcinomas UV: ultraviolet INTRODUCTION Field cancerization in organ transplant recipients (OTRs) is a frequent occurrence, setting the stage for multiple squamous cell carcinomas (SCCs). Immunosupp...

A variety of pathologic variants of cutaneous squamous cell carcinoma (SCC) has been reported, and the signet-ring variant of cutaneous SCC is extremely uncommon. We reported an 83-year-old man with signet-ring SCC arising on the back of the finger. As far as we know, only 4 cases have been described in detail, and one dermatopathologic report focused on the presence of signet-ring cells briefl...

In xeroderma pigmentosum, a rare genodermatosis, transmitted as an autosomal recessive disorder, excessive solar damage to the skin develops at an early age. The disease is characterized by cutaneous, ocular, neurological and oral changes. Oral features in the form of early development of squamous cell carcinoma, usually at the lower lip and tip of the tongue may be seen. The disorder is associ...

Actinic keratosis (AK) is considered as superficial squamous cell carcinoma. Chronic sun exposure plays a central role in its pathogenesis. In particular, ultraviolet B radiation causes direct damage to the DNA, producing pyrimidine dimers that suppress the protective role of p53. Other risk factors include advanced age, male sex, and fair skin type. Even some drugs used for treating blood hype...

INTRODUCTION Factitious cheilitis is a chronic condition characterized by crusting and ulceration that is probably secondary to chewing and sucking of the lips. Atopy, actinic damage, exfoliative cheilitis, cheilitis granulomatosa or glandularis, contact dermatitis, photosensitivity reactions and neoplasia should be considered in the differential diagnosis of crusted and ulcerated lesions of th...

Actinic keratoses (AKs) are defined clinically as erythematous and scaly plaques occurring on chronically sun-damaged skin as a result to exposure to ultraviolet radiation. They are typically located on the face, the scalp, the neck, and the extremities. It is said that ‘their potential for malignant transformation is well documented’ (1), because of several mechanisms of ultraviolet-induced da...

Patients with photodermatoses or actinic keratosis benefit from very high ultraviolet B-ultraviolet A (UVB-UVA) photoprotection. However, poor compliance is an issue that jeopardizes adequate protection, leading to disease recurrence. This study evaluated the efficacy of a daily protective moisturizer with high UVB and UVA photoprotection applied 8 h before irradiation. A monocentric, open-labe...

Patients with venous disease often exhibit dermatological changes. Sometimes these skin changes are the only clue to an appropriate list of differential diagnoses. Venous insufficiency is the most common venous disease which presents with a range of skin changes. Most people are familiar with venous eczema, lipodermatosclerosis and venous ulcers as manifestations of long-term venous insufficien...

Erlotinib is an inhibitor of the tyrosine-kinase domain of the epidermal growth factor receptor-1 (EGFR). This drug is used to treat some solid cancers, particularly advanced non-small-cell lung carcinoma. Similar to other EGFR inhibitors, erlotinib is responsible for a series of skin adverse reactions, particularly acneiform lesions. We described the incidental effect of erlotinib on actinic k...