Abstract Immunotherapy has provided a new avenue to treat metastatic cancers, which result in ?90% of cancer related deaths. However, current immunotherapies, such as immune checkpoint therapy (ICT), have met with limited success, primarily due tumor intrinsic and extrinsic factors that inhibit antitumor responses. To overcome the suppression microenvironment (TME) enhance tumoricidal activity ...

Lasers have been used in a variety of industries, but we will concentrate on their use medicine, specifically dermatology. I concentrated three types lasers this article (ablation, non-ablative lasers, and fractional lasers). The laser causes skin contraction as result wound stimulation collagen during the healing phase dermis, upper thermal ablation. Laser ablation is more dangerous because it...

objectives this study aimed to evaluate the efficacy of afcl in improvement of hand photoaging in 25 patients. patients and methods a prospective, before- after, single blind study was conducted in 25 patients who presented for desired treatment of hand photoaging. patients received three treatments sessions with afcl. results all enrolled patients were female and received three treatment sessi...

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Established ablative therapies for the treatment of primary and secondary liver tumours, including percutaneous ethanol injection, cryotherapy, and radiofrequency ablation, are discussed. Newer techniques such as magnetic resonance imaging guided laser interstitial thermal therapy of liver tumours has produced a median survival rate of 40.8 months after treatment. The merits of this newly emerg...

Head and neck squamous cell carcinoma (HNSCC) has a reported average of around 15% metastases at presentation with chemotherapy being the mainstay of treatment for widely metastatic disease. However, in select patients with oligometastatic disease, local ablative therapy (commonly including surgery or radiotherapy) can be utilized with the possibility of improving survival, decreasing morbidity...

With widespread utilization of noninvasive cross-sectional abdominal imaging, small solid renal masses are being found with increasing frequency 1. These small tumours are often discovered incidentally by abdominal ultrasound or computer tomography (CT). These incidentally discovered renal tumours are generally slower growing, are detected at an earlier stage, and are localized to the kidney 2,...

T en years ago, the only available treatment modality for patients with drug-refractory supraventricular tachycardia was surgery. Surgical techniques included direct dissection or cryodesiccation of the His bundle for tachycardia control.1'2 During the past decade, catheter techniques have been introduced that replicate the surgical experience without the expense and morbidity associated with c...

BACKGROUND Catheter ablation has evolved as a possible curative treatment modality for atrial tachyarrhythmia (AT) in patients with congenital heart defects (CHD). However, data on long-term outcome are scarce. We examined characteristics of recurrent AT after ablation of postoperative AT during long-term follow-up in CHD patients. METHODS AND RESULTS CHD patients (n=53; 27 men; age, 38+/-15 ...

T en years ago, the only available treatment modality for patients with drug-refractory supraventricular tachycardia was surgery. Surgical techniques included direct dissection or cryodesiccation of the His bundle for tachycardia control.1'2 During the past decade, catheter techniques have been introduced that replicate the surgical experience without the expense and morbidity associated with c...