Nine compounds, 3-hydroxy-4,5-dimethoxyphenyl-beta-D-glucopyranoside (1), beta-D-fructfuranosyl-alpha-D-(6-vanilloyl)-glucopyranoside (2), beta-D-fructfuranosyl-alpha-D-(6-syringyl)-glucopyranoside (3), 3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-2-[4-(3-hydroxy-1-(E)-propenyl)-2-methoxyphenoxy]propyl-beta-D-glucopyranoside (4), 3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-2-[4-(3-hydroxy-1-(E)-propenyl...

Background: Abnormal accumulation of lipids is found in dopamine neurons and resident microglia the substantia nigra patients with Parkinson’s disease (PD). The an important risk factor for PD. Previous studies have mainly focussed on lipid metabolism peripheral blood, but little attention has been given to cerebrospinal fluid (CSF). We drew lipidomic signature CSF from PD evaluated role as bio...

This work investigated the association of acute ethanol and aminophylline administration on behavioral models of depression and prefrontal monoamine levels (i.e. norepinephrine and dopamine) in mice. The animals received a single dose of ethanol (2 g/kg) or aminophylline (5 or 10 mg/kg) alone or in association. Thirty minutes after the last drug administration, the animals were assessed in beha...

The acetylation modification process of histone has an essential role in the epigenetic regulation gene expression. This is controlled by balance between deacetylases (HDAC) and acetyltransferases (HAT). HDACs are thought to be vital for cell function. Particularly, higher HDAC expression frequent various cancers, resulting dysregulation several target genes involved proliferation, differentiat...

a b s t r a c t a 36-year-old male patient with posttraumatic cervical cord damage and resultant quadriparesis, demonstrated hypotension and periods of bradycardia. for most of his two-month stay in the intensive care unit (icu), he was dependent on dopamine support to maintain hemodynamic stability. keeping in mind evidence from the literature, that electrostimulation of acupoints neiguan (pc ...