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Cartwright-Hatton S, Roberts C, Chitsabesan P, et al. Systematic review of the efficacy of cognitive behaviour therapies for childhood and adolescent anxiety disorders. Br J Clin Psychol 2004;43:421–36. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...
We explore the axion-like particle (ALP)-photon oscillation effect in $\gamma$-ray spectra of blazars Markarian 421 (Mrk 421) and PG 1553+113, which are measured by Major Atmospheric Gamma Imaging Cherenkov Telescopes (MAGIC) Fermi Large Area Telescope (Fermi-LAT) with high precision. investigate constraints on ALP parameter space using Mrk 1553+113 observations 15 5 phases, respectively. find ...
Brachypodium distachyon has been proposed as a model plant for agriculturally important cereal crops such as wheat and barley. Seed coat colour change from brown-red to yellow was observed in a mutant line (142-3) of B. distachyon, which was induced by chronic gamma radiation. In addition, dwarf phenotypes were observed in each of the lines 142-3, 421-2, and 1376-1. To identify causal mutations...
Estrogen receptor (ER) b1 and its splice variants are expressed both in ovary and ovarian cancer. We studied the role of ERb1 and two of its splice variants in regulation of gene expression, cellular proliferation, apoptosis, and migration of an ovarian cancer cell line. In this study, we transfected SK-OV-3 ovarian cancer cells with vectors coding for ERb1 or its splice variants ERb-d125 and E...
p70S6 kinase (S6K1) plays a pivotal role in hypertrophic cardiac growth via ribosomal biogenesis. In pressure-overloaded myocardium, we show S6K1 activation accompanied by activation of protein kinase C (PKC), c-Raf, and mitogen-activated protein kinases (MAPKs). To explore the importance of the c-Raf/MAPK kinase (MEK)/MAPK pathway, we stimulated adult feline cardiomyocytes with 12-O-tetradecan...
The CAT (Cerenkov Array at Thémis) γ-ray detector 1 operates above 250 GeV since Autumn 1996. Its observation program has been largely devoted to the study of blazars. These objects are radio-loud active galactic nuclei (AGN’s) with a relativistic jet which is pointed directly to the observer. The jet emission dominates that of the accretion disk (and of the host galaxy) over a large energy dom...
Although the existence of large-scale hot gaseous halos around massive disk galaxies have been theorized for a long time, there is yet very little observational evidence. We report the Chandra and XMM-Newton grating spectral detection of O VII and Ne IX Kα absorption lines along the sight-line of 4U 1957+11. The line absorption is consistent with the interstellar medium in origin. Attributing t...
We have examined 40 NuSTAR light curves (LCs) of five TeV emitting high synchrotron peaked blazars: 1ES 0229+200, Mrk 421, Mrk 501, 1ES 1959+650 and PKS 2155−304. Four of the blazars showed intraday variability in the NuSTAR energy range of 3–79 keV. Using an auto correlation function analysis we searched for intraday variability timescales in these LCs and found indications of several between ...
The regulation of transcription and genome stability by epigenetic systems are crucial for the proper development of mammalian embryos. Chemicals that disturb epigenetic systems are termed epimutagens. We previously performed chemical screening that focused on heterochromatin formation and DNA methylation status in mouse embryonic stem cells and identified five epimutagens: diethyl phosphate (D...
We expressed a protein in Saccharomyces cerevisiae in order to evaluate the humoral immune responses to the C-terminal region of the merozoite surface protein 1 of Plasmodium vivax. This protein (Pv200(18)) had a molecular mass of 18 kDa and was reactive with the sera of individuals with patent vivax malaria on immunoblotting analysis. The levels of immunoglobulin M (IgM) and IgG antibodies aga...
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