The pyrrole derivatives la, b and 2a, b were used as precursors for the preparation of N-substituted pyrrole derivatives 3a, b-9a, b and pyrrolo[2,3-d]pyrimidines 13-16. Also, all the newly prepared products were tested for anti-inflammatory activity as analogues to fenamates, and some of them revealed moderate anti-inflammatory activity compared to the standard drug indomethacin.

One of the main directions steroid research is preparation modified derivatives in which, addition to changes physicochemical properties, receptor binding significantly altered, thus a bioactivity different from that parent compound predominates. In frame this work, 2-arylidene were first synthesized by regioselective modification A-ring natural sex hormone, 5α-dihydrotestosterone (DHT). After ...

A method is described for using the cross-linking reagent 4'-(hydroxy-methyl)-4,5',8-trimethylpsoralen (HMT) to map base paired regions and higher-order structure within RNA molecules. Applying this method to yeast tRNAPhe, we have specifically identified cross-links within the acceptor stem between U6 X U68, in the D-stem between C11 X C25, and in the T psi-stem between U50 X C63 and U52 X C63...

The incorporation in vivo of compounds labeled with N15 or Cl4 into the purines and pyrimidines of nucleic acid has been repeatedly demonstrated (e.g. (l-3)). W e wish to report observations on the incorporation of radioactive erotic acid in vitro into the pyrimidines of the nucleic acid of rat liver slices. It is believed that this procedure will readily permit the study of precursors of nucle...

A copper catalyzed one-pot, three component reaction between barbituric acid, aldehydes and terminal alkynes has been developed for the construction of pyrano[2,3-d]pyrimidines via a tandem conjugative alkynylation/6-endo cyclization pattern. Screening of barbituric acid derived organic acceptors in conjugative alkynylation reaction and the synthetic applicability of conjugative addition produc...

Dihydro [2,3D] pyridine substituted enaminosulfonamide compounds have been synthesized and their effects on carbonic anhydrase II (hCAII) evaluated. Pyrido [2,3 d] pyrimidines were from barbituric acid derivatives, malonanitrile, aldehyde derivatives in basic condition then hydrolyzed with hydrochloric acid. The targeted syn-thesized amino sulfanilamide, dihydro compounds, triethylorthoformate....

A short and practical synthesis of 2,3-substituted imidazo[1,2-a]pyrimidines, based on microwave-assisted Heck-type arylation of 2-substituted imidazo[1,2-a]pyrimidines, was developed. A 45-membered library of 2,3-substituted imidazo[1,2-a]pyrimidines was obtained with good yields and purities using this optimized protocol.

Accepted September 28, 2012 In the present study, a series of benzothiazol derivatives 3a-l containing pyrazolo[3,4-d]pyrimidine moiety at the second position were synthesized and characterized by analytical and spectral data. The compounds were tested for their in vitro antimicrobial activity. Compounds 1-(1,3-benzothiazol-2yl)-3-methyl-4-phenyl-1H-pyrazolo[3,4-d]pyrimidine (3a), 1(1,3-benzoth...