نتایج جستجو برای: 2dg electrophoresis

تعداد نتایج: 50889  

2003
IAN R. HAMILTON

The growth of Streptococcus mutans Ingbritt in continuous culture at low pH or high growth rates repressed the biosynthesis of the components of the phosphoenolpyruvate:sugar phosphotransferase system (PTS). The cellular concentrations of the soluble components HPr, enzyme I (El), and EIII for mannose (IlIma") and EII activity for glucose, mannose, 2-deoxyglucose (2DG), and fructose were determ...

2015
Dong-Hee Choi Ji-Hye Kim Kyoung-Hee Lee Hahn-Young Kim Yoon-Seong Kim Wahn Soo Choi Jongmin Lee

The molecular mechanism underlying the selective vulnerability of neurons to oxidative damage caused by ischemia-reperfusion (I/R) injury remains unknown. We sought to determine the role of NADPH oxidase 1 (Nox1) in cerebral I/R-induced brain injury and survival of newborn cells in the ischemic injured region. Male Wistar rats were subjected to 90 min middle cerebral artery occlusion (MCAO) fol...

Journal: :American journal of physiology. Endocrinology and metabolism 2010
Tsutomu Wada Satoko Hori Maine Sugiyama Eriko Fujisawa Tetsuro Nakano Hiroshi Tsuneki Kiyofumi Nagira Shigeru Saito Toshiyasu Sasaoka

Maternal insulin resistance is essential for efficient provision of glucose to the fetus. Although elevation of placental hormones is known to relate to the development of insulin resistance, the precise underlying mechanism of maternal insulin resistance is unknown. Therefore, we examined the molecular mechanisms of progesterone causing insulin resistance in 3T3-L1 adipocytes. Progesterone at ...

Journal: :American journal of physiology. Endocrinology and metabolism 2001
Q Mei T O Mundinger D Kung D G Baskin G J Taborsky

To develop an index of the activation of abdominal sympathetic nerves, we used Fos immunostaining of the celiac ganglion (CG) taken from rats receiving nicotine, preganglionic nerve stimulation, or glucopenic agents. Subcutaneous nicotine injection moderately increased Fos expression in the principal ganglionic cells of the CG (17 +/- 4 Fos+ per mm(2), approximately 12% of all principal CG cell...

2016
Simona Kavaliauskiene Maria Lyngaas Torgersen Anne Berit Dyve Lingelem Tove Irene Klokk Tuulia Lintonen Helena Simolin Kim Ekroos Tore Skotland Kirsten Sandvig

2-fluoro-2-deoxy-D-glucose (FDG), labeled with 18F radioisotope, is the most common imaging agent used for positron emission tomography (PET) in oncology. However, little is known about the cellular effects of FDG. Another glucose analogue, 2-deoxy-D-glucose (2DG), has been shown to affect many cellular functions, including intracellular transport and lipid metabolism, and has been found to imp...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1999
A Schurr J J Miller R S Payne B M Rigor

Aerobic energy metabolism uses glucose and oxygen to produce all the energy needs of the brain. Several studies published over the last 13 years challenged the assumption that the activated brain increases its oxidative glucose metabolism to meet the increased energy demands. Neuronal function in rat hippocampal slices supplied with 4 mM glucose could tolerate a 15 min activation by a 5 mM conc...

Journal: :Hearing research 1989
D Durham E W Rubel K P Steel

Deafness mutant mice show no stimulus-related cochlear potentials as well as abnormal electrically-evoked responses recorded from the inferior colliculus. Abnormal spontaneous activity in the auditory periphery could result in abnormal development and/or maintenance of the central auditory pathways. We therefore assessed spontaneous activity of cochlear origin in the central nuclei of the mutan...

Journal: :Molecular cancer research : MCR 2013
Ling-Ling Liu Zi-Jie Long Le-Xun Wang Fei-Meng Zheng Zhi-Gang Fang Min Yan Dong-Fan Xu Jia-Jie Chen Shao-Wu Wang Dong-Jun Lin Quentin Liu

Aurora kinases are overexpressed in large numbers of tumors and considered as potential therapeutic targets. In this study, we found that the Aurora kinases inhibitors MK-0457 (MK) and ZM447439 (ZM) induced polyploidization in acute myeloid leukemia (AML) cell lines. The level of glycolytic metabolism was significantly increased in the polyploidy cells, which were sensitive to glycolysis inhibi...

Journal: :Biological research 2003
Hardy Thomas Vladimir López

Topographic distributions and laminar pattern of cortico-cortical projections from the primary auditory field (AI), anterior auditory field (AAF), dorsoposterior field (DP), ventroposterior field (VP), dorsal field (D) and ventral field (V) were studied in relation to tonotopic maps in combined anatomical, electrophysiological and 2-deoxyfluoro-D-glucose (2DG) experiments. Distributions of axon...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1990
T S Kilduff J D Miller C M Radeke F R Sharp H C Heller

Neuronal activity underlying various phases of the mammalian hibernation cycle was investigated using the 14C-2-deoxyglucose (2DG) method. Relative 2DG uptake (R2DGU) values were computed for 96 brain regions across 7 phases of the hibernation cycle: euthermia, 3 body temperature (Tb) intervals during entrance into hibernation, stable deep hibernation, and 2 Tb intervals during arousal from hib...

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