It is known that androst-5-ene-3b,17b-diol (Adiol), a precursor of testosterone (T), can activate estrogen target genes. The androgenic activity of Adiol itself, however, is poorly understood. Using a transient transfection assay, we here demonstrate in human prostate cancer cells that Adiol can activate androgen receptor (AR) target genes in the presence of AR, and that AR coactivator ARA70 ca...


 Prima Cahaya Abadi adalah salah satu perusahaan yang bergerak di bidang industri usaha pengolah kayu didirikan Jl. Mayjen Sungkono 17B Gresik. Terjadi 223 kali kerusakan pada mesin produksi balok yaitu Mesin Benzo Type A, diantaranya gergaji patah, roda gila renggang, switch trouble, metal penjepit renggang dan tanganan naik turun, sehingga tersebut tidak dapat bekerja dengan efektif. Se...

The intermediate metabolism of androgens has been the subject of many investigations by incubation of liver slices and homogenates with testosterone or other suitable (319 compounds (l-4). The enzymatic reduction of the a,Bunsaturated ketone in ring A (4) and the oxidation of the C-17 hydroxyl group (1, 4) have been the major transformations demonstrated. However, Schneider and Mason (5) have s...

ÐUtilization of 17-keto-androstanes as starting materials for the synthesis of aor b-oriented steroidal 20!16-g-carbolactones has been explored following two di€erent strategies. A highly ecient, stereospeci®c protocol has been developed for the boriented cis-g-lactone. A di€erent approach, involving prior attachment of a 3-carbon side chain on C-17 of a 17-oxo-16b-acetoxyandrostane led to the...

Corydaline is a bioactive alkaloid with various antiacetylcholinesterase, antiallergic, and antinociceptive activities found in the medicinal herb Corydalis Tubers. The inhibitory potential of corydaline on the activities of seven major human cytochrome P450 and four UDP-glucuronosyltransferase enzymes in human liver microsomes was investigated using LC-tandem MS. Corydaline was found to inhibi...