A series of Vinca alkaloids were found to block polymerization of crude tubulin extracts of porcine brain in a dose-dependent manner. This appears to be a specific effect occurring at low concentrations of drug. The concentration of vinblastine that prevents polymerization by 50% was 4.3 x 10(-7) mole/liter for a tubulin concentration of 3.0 mg/ml, and this concentration is consistent with leve...

Alopecia areata is common scalp complaint, seen in any age group. It an auto immune disorder effecting the hair follicles, causing loss of patches. constitutes a life time risk approximately 2%. does not carry significant sex or ethnic predominance. Peak incidence occurs second and third decades most patients experience onset before fourth decade. Homoeopathy 2nd widely used therapy all over wo...

Inadvertent intrathecal vincristine administration causes fatalities.

When tumor cells are chronically treated with antitumor drugs such as vinca alkaloids or anthracyclines, they often acquire resistance not only to the same drugs but also to other antitumor drugs1~3). Although the mechanism of this pleiotropic drug resistance is not fully understood, decreased uptake and retention of doxorubicin ( = adriamycin, ADM) and daunorubicin ( = daunomycin, DNR) in drug...

Application of green walls still has not attracted interest among the contractors and people, and this can be due to poor growing performance of the plants on these systems. This study investigated the effect of four growing media types (30% cocopeat + 65% perlite + 5% vermicompost, 30% soil + 65% perlite + 5% vermicompost, 30% mushroom compost + 65% perlite + 5% vermicompost and regular soil a...