نتایج جستجو برای: vaca c

تعداد نتایج: 1057856  

Journal: :Journal of infection in developing countries 2013
George Krashias Stavros Bashiardes Alexia Potamitou George S Potamitis Christina Christodoulou

INTRODUCTION The prevalence of H. pylori varies with geographic locations. To date there are no epidemiological data on its prevalence in Cyprus; therefore, we determined the prevalence and molecular characteristics of H. pylori infection in Cypriot patients. METHODOLOGY DNA extracted from 103 gastric biopsies was analyzed for the presence of H. pylori by PCR using primers for ureA. H. pylori...

Journal: :Journal of clinical pathology 1998
V J Warburton S Everett N P Mapstone A T Axon P Hawkey M F Dixon

AIMS To determine the relation among the cytotoxin associated gene (cagA) and vacuolating cytotoxin gene (vacA) status of Helicobacter pylori isolates, the associated clinical diseases, and the severity and pattern of chronic gastritis. METHODS Helicobacter pylori was cultured from gastric biopsies obtained from dyspeptic patients. DNA was extracted from the isolates and the cagA and vacA sta...

Journal: :Journal of clinical microbiology 2004
Daniel Asrat Ingrid Nilsson Yohannes Mengistu Endale Kassa Senait Ashenafi Kiros Ayenew Torkel Wadström Waleed Abu-Al-Soud

A total of 300 gastric biopsy samples and 50 Helicobacter pylori isolates were collected from Ethiopian adult dyspeptic patients. The vacA and cagA genes were detected in 90 and 79% of biopsy specimens, respectively, and in 100 and 87% of clinical isolates, respectively. Both genes were detected in 84% of the gastric biopsy samples and in 87% of the clinical isolates. Among vacA genotypes, the ...

2009
Javed Yakoob Shahab Abid Zaigham Abbas Wasim Jafri Zubair Ahmad Rashida Ahmed Muhammad Islam

BACKGROUND Helicobacter pylori (H. pylori) infection is known to be associated with a spectrum of gastroduodenal diseases. We studied the association of H. pylori virulence markers cytotoxin-associated gene (cagA) and vacuolating associated cytotoxin gene (vacA) alleles in patients with non ulcer dyspepsia (NUD), gastric ulcer (GU), gastric carcinoma (GC) and duodenal ulcer (DU). METHODS H. p...

Journal: :BMC Gastroenterology 2002
Gustavo Faundez Miriam Troncoso Guillermo Figueroa

BACKGROUND The cytotoxin associated gene A (cagA), and the vacuolating cytotoxin gene A (vacA) of Helicobacter pylori have been associated to phenotypic characteristics of virulence. The objectives of this study were to detect the presence of cagA and to characterize the allelic variants of vacA in 63 strains of H. pylori isolated from colonized individuals with different clinical outcomes. M...

Journal: :Microbiology 1999
V Pelicic J M Reyrat L Sartori C Pagliaccia R Rappuoli J L Telford C Montecucco E Papini

Polarized epithelial monolayers of Madin-Darby canine kidney (MDCK) cells were used to study the pathogenicity of Helicobater pylori, with an emphasis on the effect of VacA. The adherence of H. pylori to MDCK monolayers resulted in a decrease in trans-epithelial resistance (TER) across the cell monolayer. Isogenic vacA mutants did not lower the TER, demonstrating that the effect is strictly lin...

Journal: :iranian journal of basic medical sciences 0
leila hasanzadeh ¹ department of biotechnology and microbiology, school of medicine, arak university of medical sciences, arak, iran ehsanollah ghaznavi-rad department of microbiology and immunology, school of medicine, arak university of medical sciences, arak, iran safieh soufian ³biology department, payame noor university, arak, iran vahideh farjadi department of microbiology, islamic azad university, qom branch, qom, iran hamid abtahi molecular and medicine research center, department of microbiology, school of medicine, arak university of medical sciences, arak, iran

objective(s): helicobacter pylori, a human specific gastric pathogen is a causative agent of chronic active gastritis. the vacuolating cytotoxin (vaca) is an effective virulence factor involved in gastric injury. the aim of this study was to construct a recombinant protein containing antigenic region of vaca gene and determine its antigenicity.   materials and methods: the antigenic region of v...

ژورنال: :دانشور پزشکی 0
زهره خدایی zohreh khodaii 1. department of medical genetics - faculty of medicine, shahid beheshti university of medical sciencesگروه ژنتیک، دانشکده پزشکی، دانشگاه علوم پزشکی و خدمات درمانی شهید بهشتی اکرم سادات طباطبایی پناه akram sadat tabatabaei panah 2. department of biology, islamic azad university, eastern tehran branchباشگاه پژوهشگران جوان، دانشگاه آزاد اسلامی، واحد تهران شرق سید محمدحسین قادریان sayyed mohammad hossein ghaderian 1. department of medical genetics - faculty of medicine, shahid beheshti university of medical sciencesگروه ژنتیک، دانشکده پزشکی، دانشگاه علوم پزشکی و خدمات درمانی شهید بهشتی رضا اکبرزاده نجار reza akbarzadeh najar 1. department of medical genetics - faculty of medicine, shahid beheshti university of medical sciencesگروه ژنتیک، دانشکده پزشکی، دانشگاه علوم پزشکی و خدمات درمانی شهید بهشتی

مقدمه و هدف: آلودگی با هلیکوباکتر پیلوری (h.pylori) یکی از شایع ترین عفونت های گوارشی در جهان به شمار می رود که می تواند باعث موارد پاتولوژیکی متفاوت، افزایش استرس اکسیداتیو و در نتیجه پاسخ های التهابی در  مخاط معده شود.  تشخیص بیماریزایی h.pylori به دلیل تخمین خطر علائم بالینی اهمیت زیادی دارد. هدف از این مطالعه، بررسی شیوع ژن های caga و vaca در عفونت h.pylori در بیماران با علائم بالینی متفاوت...

Journal: :journal of medical bacteriology 0
hashem fakhre yaseri 1 gastroenterology, research center for gastroenterology and liver disease, firoozgar hospital, iran university of medical sciences, tehran, iran. 2 department of internal medicine, firoozgar hospital, iran university of medical sciences, tehran, iran. mehdi shekaraby immunology research center, iran university of medical sciences, tehran, iran. hamid reza baradaran department of epidemiology, iran university of medical sciences, tehran, iran. seyed kamran soltani arabshahi department of internal medicine, firoozgar hospital, iran university of medical sciences, tehran, iran.

background: helicobacter pylori strains have two classical virulence genes, the cytotoxinassociated a ( caga ) gene and the vacuolating cytotoxin a ( vaca ) gene, which are located in the cag pathogenicity island ( cag pai). serum immunoglobulin g (igg) antibodies to h. pylori , especially, the caga antigen may be a reliable marker for selection of dyspeptic patients for upper endoscopy. method...

Journal: :iranian journal of pathology 2009
forough foroughi mahsa molaei reza mashayekhi hossein dabiri leila shokrzadeh

background and objective: helicobacter pylori has several strains with different degrees of virulence. the aim of this study was to detect two major important virulence factors, caga/vaca genotypes, and to determine correlations among different caga/vaca genotypes and histological features of chronic gastritis in iranian patients. methods: in this cross- sectional study, gastric biopsy was take...

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