Cancer multidrug resistance (MDR) is one of the main mechanisms contributing to therapy failure and mortality. Overexpression drug transporters ABC family (ATP-binding cassette) a major cause MDR. Extracellular vesicles (EVs) are nanoparticles released by most cells organism involved in cell–cell communication. Their cargo mainly comprises, proteins, nucleic acids, lipids, which transferred fro...

This paper asks how rule-consequentialism might adapt to very adverse futures, and whether moderate liberal consequentialism can survive into broken futures and/or where humanity faces imminent extinction. The first recaps the recent history of rule-consequentialist procreative ethics. It outlines rule-consequentialism, extends it cover future people, applies futures. then introduces a new thou...