An aryl alkyl thioether, in which the C−S bond is split by a lightning bolt, featured on cover picture illustrating Research Article Mårten Ahlquist, Helena Lundberg et al. (e202304272). The background shows two distinct sections: left showcasing crystalline sulfur and right representing layers of coal. image illustrates use electricity to break bonds for synthetic applications. We thank Dr And...

A tandem 1,3-sulfur migration followed by iodocyclization reaction of propargylic sulfides in the presence NIS HFIP has been developed to synthesize indene-based β-iodoalkenyl sulfides. The choice media is crucial promote reaction. proposed mechanism involving initial activation and favoring sulfur starting thioether via cationic intermediates experimentally supported. In addition, suitability ...

By utilizing thioether ligands, CuproCleav-1 stabilizes Cu(+) complexes in aqueous solution and releases the guest metal ion upon photolysis of the nitrobenzyl group. The photocage has an apparent K(d) of 54 pM for Cu(+), and metal ion release has been demonstrated using the fluorescent sensor CS1.

This study demonstrates for the first time that a thioether-containing peptide, an azurin fragment, can be translocated via the Sec pathway. This methyl-lanthionine was introduced by the nisin modification enzymes. The Sec pathway can therefore be a successful alternative for those cyclized peptides that are inefficiently transported via NisT.

We have devised a protocol for enzyme-free insertion of dehydroalanine, dehydrobutyrine and thioether crosslinks into translated peptides. In vitro translation using 4-selenalysine and 4-selenoisoleucine as substitutes for lysine and isoleucine yields peptides that can be converted to polycyclic structures using mild chemistry in water. This methodology presents a gateway for exploring the pote...

The mononuclear Pd(ii) complex cis-[PdCl(2)([9]aneS(3))]([9]aneS(3)= 1,4,7-trithiacyclononane) converts at 44 kbar pressure into an intensely coloured chain polymer, which exhibits distorted octahedral co-ordination at the metal centre and an unprecedented [1233] conformation for the thioether crown.

We have described the first successful application of non-N-donor heterodonor ligands--thioether-phosphite ligands--in the Ir-catalyzed hydrogenation of minimally functionalized olefins. Excellent enantioselectivities (ee's up to 99%) have been obtained for a range of substrates, including challenging terminal disubstituted substrates, under standard conditions.

A series of 2-alkylsulfanyl-4-(4-fluorophenyl)-5-(2-aminopyridin-4-yl)-substituted imidazoles was prepared and interaction possibilities of the 2-thioether moiety with phosphate/ribose binding pockets of p38 MAP kinase were investigated. Introduction of the alkyl/benzyl amino function at the pyridine moiety was carried out via nucleophilic substitution or via palladium catalyzed aryl-C-N-bond f...

Gallidermin (Gdm) and epidermin (Epi) are highly homologous tetracyclic polypeptide antibiotics that are ribosomally synthesized by a Staphylococcus gallinarum strain and a Staphylococcus epidermidis strain, respectively. These antibiotics are secreted into media and are distinguished by the presence of the unusual amino acids lanthionine, 3-methyllanthionine, didehydrobutyrine, and S-(2-aminov...