Background: No definitive epidemiological evidence is available on SARS-CoV-2 lethality during the surge of different variants concern (VoCs) and coronavirus disease 2019 (COVID-19) vaccination in relation to common flu fatality.

Interactions between excitatory amino acids and opioids were examined by studying the ability of the noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 to affect morphine catalepsy and lethality. MK-801 (0.3 mg/kg) reduced the ED50 for morphine-induced catalepsy from approximately 30 mg/kg to less than 10 mg/kg, and reduced the LD50 for morphine from approximately 100 mg/kg t...

Methamphetamine (MA) toxicity in aggregated mice was studied by varying the number of mice and the proportion of MA treated mice kept in the same confined space. The lethality was measured 24 h after intraperitoneal injections of MA at doses ranging from 10 to 100 mg/kg. MA lethality, over a wide dose range (15 to 50 mg/kg), was higher in aggregated mice than in those maintained in isolation. T...

treatment with carbenoxolone sodium resulted in thc increase of free and bound sialic acids to those values found in normal subjects, but no increase above control values was observed. The work now reported shows that treatment of normal adult rats with carbenoxolone results in significant increases in a number of components of the gastric mucus and mucosa. This may be related to the mechanism ...

A series of Pictet-Spengler condensation derivatives (tetrahydro-β-carbolines) was designed, synthesized and evaluated for lethality against a panel of seven cancer cell lines. Seven compounds (2a, 13, 20, 21, 27, 29 and 34) showed lethality in at least five cell lines. Among these, compound 27 showed a unique selectivity towards oncogenic-RAS expressing BJ-TERT/LT/ST/RAS(V12) tumor cells, comp...

Understanding the inactivation kinetics of bacterial spores during combined pressure-thermal processing is essential for process design. The knowledge on influence pH and water activity ( a w ) treatment limited. Experiments were conducted using Bacillus cereus suspended in citrate-phosphate buffers, adjusted to different levels (3.8–7.3) (0.80–0.99). Spores then treated with pressure-heat comb...