Background: Obliterative bronchiolitis in chronic rejection of lung allografts is characterised by airway epithelial damage and fibrosis. The process whereby normal epithelium is lost and replaced by fibroblastic scar tissue is poorly understood, but recent findings suggest that epithelial cells can become fibroblasts through epithelial-mesenchymal transition (EMT). It is hypothesised that EMT ...

Interstitial flow emanates from tumors into the microenvironment where it promotes tumor cell invasion. Fibroblasts are key constituents of the tumor stroma that modulate the mechanical environment by matrix remodeling and contraction. Here, we explore how interstitial fluid flow affects fibroblast–tumor cell interactions. Using a 3-dimensional invasion assay and MDA-MB-435S cells cocultured wi...

Nonobese diabetic/severe combined immunodeficient (NOD/ SCID) mice transplanted with human cord blood or adult marrow cells and injected 6 weeks posttransplant with 2 daily doses of transforming growth factor-b1 (TGF-b1), monocyte chemoattractant protein-1 (MCP-1), or a nonaggregating form of macrophage inflammatory protein-1a (MIP-1a) showed unique patterns of inhibition of human progenitor pr...

The acute-phase response (APR) represents a systemic reaction of the organism to multiple nonspecific inflammatory stimuli. In general, it is protective for the host, and hepatocytes are the main cells responding with alterations in the expression of a set of liver-specific proteins named the acute-phase proteins. We have previously shown that although a turpentine-induced APR is not fibrogenic...

Background: The relationship between airway structural changes and inflammation is unclear in early cystic fibrosis (CF) lung disease. A study was undertaken to determine changes in airway remodelling in children with CF compared with appropriate disease and healthy controls. Methods: Bronchoalveolar lavage and endobronchial biopsy were performed in a cross-sectional study of 43 children with C...

Neural stem cells (NSCs) transplantation has been proposed as a means of restoring damaged brain tissue, a possibility rendered more likely by reports of low NSCs immunogenicity in various experimental models because of low expression of MHC class I and II as well as co-stimulatory molecules. We investigated the immunogenicity of a human NSC line grown in normal culture conditions and in the pr...

Oral mucosa heals faster than does skin, yet few studies have compared the repair at oral mucosal and cutaneous sites. To determine whether the privileged healing of oral injuries involves a differential inflammatory phase, we compared the inflammatory cell infiltrate and cytokine production in wounds of equivalent size in oral mucosa and skin. Significantly lower levels of macrophage, neutroph...

Mięśniak gładkokomórkowy macicy (Leiomyoma uteri) jest niezłośliwym nowotworem monoklonalnym złożonym z komórek mięśni gładkich i zrębu zbudowanego z włóknistej tkanki łącznej. Najczęściej jest umiejscowiony w błonie mięśniowej macicy u kobiet w wieku rozrodczym. Czynnikami mogącymi przyspieszać jego wzrost są ciąża i terapia hormonalna. Jest to także guz pośrednio zależny od stężenia hormonów ...

Background Omalizumab represents a novel approach to the treatment of asthma, inhibiting the inflammatory cascade before it starts. As it was previously reported, the increase in the eosinophil levels in allergic asthma was due to the increase in peripheral blood eosinophil survival promoted by TRAIL. And as an apoptotic molecule TRAIL also present in cells that involved in asthma including eos...

the prevalence of non-alcoholic fatty liver disease (nafld) has markedly increased, especially in patients exhibit one or more features of the metabolic syndrome. this study investigates the effect of rosuvastatin (rsv) and/or b-carotene (bc) in nafld-induced rats. rats were classified into nine groups; normal (i), nafld-induced with high-fat diet (hfd; ii), nafld switched to regular diet (rd; ...