PURPOSE To determine whether swelling-activated Cl- currents (ICl,swell) observed in isolated nonpigmented ciliary epithelial (NPE) cells contribute to Cl- secretion across the ciliary epithelium. METHODS Ion transport across intact bovine ciliary epithelium was monitored electrically. Native isolated bovine NPE cells were harvested enzymatically. Cell volume changes were measured by calcein-...

Purpose Trabecular meshwork (TM) cell volume is a determinant of aqueous humor outflow resistance, and thereby IOP. Regulation of TM cell volume depends on chloride ion (Cl-) release through swelling-activated channels (ICl,Swell), whose pore is formed by LRRC8 proteins. Chloride ion release through swelling-activated channels has been reported to be regulated by calcium-activated anoctamins, b...

S U M M A R Y We reassess the applicability of the thermal plate cooling model to the subsidence of the North Pacific, Atlantic and North Indian Ocean Basins. We use a new numerical plate model in which the thermophysical parameters of the lithosphere vary with temperature according to the results of laboratory experiments, and the ridge temperature structure is consistent with the thickness of...

A swell produced by the Hurricane Omar touched the west Guadeloupean coasts during the period of the 15 to the 17 in October 2008. The waves of this swell hit different islands of the Greater and Lesser Antilles arc. The cost of the destruction of this swell was evaluated at $ 46 million. On the island of Basse-Terre in the archipelago of Guadeloupe all the exposed zone, the quiet west coast wa...