نتایج جستجو برای: sustained virological responses

تعداد نتایج: 476190  

Memory formation is the most important aspect of a vaccine which can guarantee long-lasting immunity and protection. The main aim of the present study was to evaluate the memory immune responses after immunization with a mini vaccine. Mice were immunized with human immunodeficiency virus-1 P24-Nef fusion peptide and then cellular and humoral immune responses were evaluated. In order to determin...

Journal: :Comparative Hepatology 2008
Sylvie Larrat Marie-Noëlle Hilleret Raphaele Germi Julien Lupo Sandrine Nicod Jean-Pierre Zarski Jean-Marie Seigneurin Patrice Morand

BACKGROUND Sequential monotherapies of nucleotide analogs used in chronic hepatitis B treatment can lead to the selection of a resistance mutation to each antiviral drug. CASE PRESENTATION A patient with chronic hepatitis B was successively treated with lamivudine monotherapy, lamivudine-adefovir dual therapy, adefovir monotherapy and again with an adefovir-lamivudine dual therapy. Lamivudine...

2016
Seungtaek Kim Kwang-Hyub Han Sang Hoon Ahn

Since its discovery in 1989, hepatitis C virus (HCV) has been intensively investigated to understand its biology and develop effective antiviral therapies. The efforts of the previous 25 years have resulted in a better understanding of the virus, and this was facilitated by the development of in vitro cell culture systems for HCV replication. Antiviral treatments and sustained virological respo...

2014
Yu He Yonghong Guo Yun Zhou Ying Zhang Chao Fan Guangxi Ji Yu Wang Zhiyuan Ma Jianqi Lian Chunqiu Hao Zhi Q. Yao Zhansheng Jia

OBJECTIVES CD100, also known as Sema4D, is a member of the semaphorin family and has important regulatory functions that promote immune cell activation and responses. The role of CD100 expression on B cells in immune regulation during chronic hepatitis C virus (HCV) infection remains unclear. MATERIALS AND METHODS We longitudinally investigated the altered expression of CD100, its receptor CD...

2018
Nghiem Xuan Hoan Hoang Van Tong Le Huu Song Christian G Meyer Thirumalaisamy P Velavan

The secosteroid hormone vitamin D has, in addition to its effects in bone metabolism also functions in the modulation of immune responses against infectious agents and in inhibiting tumorigenesis. Thus, deficiency of vitamin D is associated with several malignancies, but also with a plethora of infectious diseases. Among other communicable diseases, vitamin D deficiency is involved in the patho...

Journal: :Journal of viral hepatitis 2004
S K Fung F Wong M Hussain A S F Lok

Lamivudine has demonstrated efficacy for the treatment of hepatitis B e antigen-negative chronic hepatitis B (e-CHB). However, treatment withdrawal after 1 year has been associated with a high rate of relapse while long-term treatment is associated with increasing risks of drug resistance. We report our treatment experience of 50 Chinese-Canadian patients with e-CHB. All patients received lamiv...

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