Aim: to analyze the dynamics of fibrosis and steatosis liver according fibroelastometry in patients with chronic hep-atitis C (CHC) after ≥ 6 months from transient elastometry (TE) achieving a sustained virologic response (SVR) antiviral therapy. Materials methods. At baseline, prospective observational study included 628 CHC known stage (F) before AVT, some whom were phased out due non-complia...

OBJECTIVE To determine the efficacy of peg-interferon-based therapy in patients refractory to previous conventional interferon-based treatment and factors predicting sustained viral response (SVR). STUDY DESIGN Analytical study. PLACE AND DURATION OF STUDY Medical Unit IV, Liaquat University Hospital, Jamshoro, from July 2009 to June 2011. METHODOLOGY This study included consecutive patie...

Chronic hepatitis C (CHC) affects approximately 170 million people worldwide, and over 3 million individuals are newly infected each year. Kim et al reported that the adjusted prevalence rate of hepatitis C virus (HCV) infection in the general Korean population is approximately 0.78%, and the prevalence has been increasing. HCV is an important cause of liver diseases, such as liver cirrhosis an...

Coinfection with hepatitis C virus (HCV) and HIV is an increasingly recognized clinical dilemma, particularly since the advent of highly active antiretroviral therapy. Several studies of this population have demonstrated both more rapid progression of liver disease and poorer overall prognosis compared to HCV monoinfected patients. Consensus guidelines, based primarily on the results of 4 major...

BACKGROUND Current guidelines recommend children be treated for hepatitis C virus (HCV) using the same principles applied in adults. There are however few published studies which assess the efficacy and safety of HCV therapy in children. METHODOLOGY/PRINCIPAL FINDINGS A systematic review of the literature was completed for studies of any design that evaluated HCV therapy in children. The prim...

BACKGROUND The Fat Mass and Obesity-Associated Protein (FTO) gene rs9939609 single nucleotide polymorphism (SNP) has been associated with obesity, metabolic syndrome, insulin resistance (IR), and type 2 diabetes mellitus in the general population. The aim of our study was to examine for the first time the association of the rs9939609 polymorphism with metabolic disturbances, liver disease and v...

In Brazil, the treatment of hepatitis C virus (HCV) infection is funded by the national public health system (SUS). To evaluate treatment results in the state of Mato Grosso, central Brazil, we have consulted the files of the office of the State Department of Health responsible for supplying such medications. We obtained information on 232 treatments of 201 patients who underwent treatment in o...

AIMS Despite the remarkable efficacy shown in clinical practice, concerns have been raised about the costs associated with direct antiviral agent (DAA) therapy. This article presents the real-life costs for DAA treatment sustained by the Italian National Health Service in the Liguria Region (Northern Italy). METHODS A retrospective analysis of the cost per care sustained for DAA treatment, re...

BACKGROUND & AIMS Although randomized trials of adults infected with hepatitis C virus (HCV) have shown that ribavirin increases the efficacy of pegylated interferon (PEG), such trials have not been performed in children. We conducted a randomized controlled trial of PEG and ribavirin, compared with PEG and placebo, in children 5 to 17 years old with chronic hepatitis C. METHODS HCV RNA-posit...

Aim: Studies of clinical outcomes in chronic hepatitis C (CHC) patients with pretreatment advanced liver fibrosis (F3) after sustained virologic response (SVR) are scarce, and most studies small cohorts retrospective nature. Our aim was to assess the following direct acting antiviral (DAA) treatment among F3 SVR. Methods: This study included 1517 receiving DAAs out-patient clinics at Egyptian L...