Toxoplasma gondii is deemed a successful parasite worldwide with wide range of hosts. Currently, combination pyrimethamine and sulfadiazine serves as the first-line treatment; however, these drugs have serious adverse effects. Therefore, it imperative to focus on new therapies that produce desired effect lowest possible dose. The designation synthesis sulfonamide-1,2,3-triazole hybrids (3a–c) w...

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare and potentially fatal adverse drug reaction associated with skin rash, fever, eosinophilia, and multiple organ injury. A number of pharmacological agents are known to cause DRESS syndrome such as allopurinol, anticonvulsants, vancomycin, trimethoprime-sulfamethoxazole, and pyrimethamine-sulfadiazine. Here, we descr...

The presence of antibiotic sulfadiazine (SFD) poses threats to the ecosystem and human health, traditional wastewater treatment processes are not ideal for removal. Therefore, it is urgent develop with high efficiency targeting sulfadiazine. This study investigated degradation mineralization mechanisms SFD by ozone-based catalysis including ozone/persulfate (PS) ozone/peroxymonosulfate (PMS). d...

The occurrence of drug resistance and plasmid-mediated transferability was investigated in 170 strains belonging to eight bacterial groups isolated from cultured rainbow trout. It was found that 87.6% of the strains were resistant to at least one drug, with the highest percentages of resistance being detected for ampicillin (54.7%), sulfadiazine (46.5%), nitrofurantoin (38.2%), and chlorampheni...

Burns remain a major public health problem all over the world, especially in developing countries. Pseudomonas aeruginosa is a major cause of infection and a contributing factor in the death of patients with burns. So, there is a growing need to develop drugs which will prevent infections and complications more effectively than the presently used drugs. Ocimum sanctum L. (Holy basil in English ...

Evidence from animal studies and trials suggests that honey may accelerate wound healing. The objective of this review was to assess the effects of honey compared with silver dressings on the healing of burn wounds. Relevant databases for randomized controlled trials (RCTs) of honey compared with silver sulfadiazine (SSD) were searched. The quality of the selected trials was assessed using the ...

The lipids from three types of organisms-a Proteus mirabilis wild type highly resistant to polymyxin B, a polymyxin B-sensitive mutant derived from the wild type, and the wild type grown in the presence of sulfadiazine resulting in phenotypic conversion to polymyxin B sensitivity-were examined to determine the nature of polymyxin B resistance. The phospholipid compositions were nearly identical...