BACKGROUND We examined the effect of chronic administration of angiotensin IV (AngIV) on the vascular alterations induced by type 1 diabetes in mice. METHODS Diabetes was induced in adult Swiss mice with a single injection of streptozotocin (STZ). Mice were treated subcutaneously with AngIV (1.4 mg/kg/day) either immediately following diabetes induction (preventive treatment), or treated with...

Active peptide from shark liver (APSL) is a cytokine from Chiloscyllium plagiosum that can stimulate liver regeneration and protects the pancreas. To study the effect of orally administered recombinant APSL (rAPSL) on an animal model of type 2 diabetes mellitus, the APSL gene was cloned, and APSL was expressed in Bombyx mori N cells (BmN cells), silkworm larvae and silkworm pupae using the silk...

Background Our recent findings have shown that the rat testis is subjected to significant oxidative stress during the early phase of diabetes induced by Streptozotocin (STZ). In the present study, we have investigated whether oral supplementation of β-carotene (BC) to pubertal rats would provide protection against diabetes associated oxidative stress in testis and liver. MaterialsAndMethods Mal...

This study investigated the effects of streptozotocin-induced diabetes on the functional integrity of the blood-brain barrier in the rat at 7, 28, 56, and 90 days, using vascular space markers ranging in size from 342 to 65,000 Da. We also examined the effect of insulin treatment of diabetes on the formation and progression of cerebral microvascular damage and determined whether observed functi...

introduction: zinc is an essential rare element that plays an important role in synaptic plasticity and modulation of the activity of central nervous system and is involved in learning and memory. increasing zinc intake may protect against conditions associated with zinc deficiency, such as diabetes. some studies have revealed that zinc deficiency in diabetic subjects is due to hogher excretion...

The effects of systemic insulin administration at different concentrations on the testicular tissue diabetic adult rats, induced by streptozotocin, are evaluated morphological analysis spermatogenic process. Twenty-four male rats were divided into 1) Control Group: they received citrate buffer, intraperitoneal injection; 2) Diabetic injection streptozotocin (60 mg. kg-1 body weight); 3) Insulin...

Aim: Diabetes Mellitus is a global public health challenge with major and potentially devastating complications, concomitant complications include retinopathy neuropathy due to hypoxia microvascular dysfunction. In this study, we investigated the effect of hyperbaric oxygen therapy as method transiently improve tissue oxygenation on diabetic in streptozotocin induced type-1 rat model (Wistar). ...

Some late complications of diabetes are associated with alterations in the structure and function of proteins due to glycation and free radicals generation. Aspirin inhibits protein glycation by acetylation of free amino groups. In the diabetic status, it was demonstrated that several enzymes of heme pathway were diminished. The aim of this work has been to investigate the in vivo effect of sho...

PURPOSE To investigate in the kidney the pathologic changes and expression of GRP78 and CHOP in the Kunming (KM) mice with combination of high-fat diet and streptozotocin-induced diabetes. METHODS Sixty two male KM mice were randomly divided into a normal control (NC) group (n=20) and a high-fat diet (HFD) group (n=42). After a four-week dietary manipulation, the KM mice in the HFD group were...