1713 Immunoepidemiological and in Vitro Studies of Possible Relationships between Australia Anti gen and Hepatocellular Carcinoma. J. A. Smith and T. I. Francis. 1721 Deamination of Arabinosyladenine by Adeno sine Dearninase and Inhibition by Arabinosyl 6-mercaptopurine. David Li-Shan Chao and A . P. Kimball. 1725 Inhibition of Tumorigenesis in Mouse Skin by Leupeptin, a Protease Inhibitor from...

Ca2+ plays a pivotal role in the regulation of hair cell function. From ,mechanoelectrical transduction at the cell's apex to the release of neurotransmitter at its base, Ca*+ acts continuously to either effect or affect diverse cellular processes. The ability of Ca'+ to perform its various local tasks rests simply on the steep gradients in the activity of Ca*+ that are encountered in the vicin...

MR-Interferographie 1] ist eine Methode in der Me-dizinischen Bildgebung, die das nichtinvasive Messen von Herzwandbewegung erm olicht 2]. Hierzu wird ein interferographisches Muster auf Kurzachsenschnitte des linken Ventrikels projiziert, welches die lokale Be-wegung des Myokards charakterisiert. Die Bestimmung phasensensitiver Parameter in der Signalverarbeitung mit Interferographie ist eine ...

C. 1). THRON. Ott th( Analysis of PharmaN)logicaI 1 xj)(’rin ents it! i ernis of tui Allosteric Receptor \IOdPl 1 B. TESTA AND P. ,JENNER. Circular Dicliroic Determination of tll(’ l (’ferr(’d Conformation of Nicotine and Related (1hiral Alkaloids in AquNnis Solution 10 H. HAQUE, I. ,J. TINSLEY, ANt) I). SCHMEI)t)ING. Lipid Binding and \Iode of Action of Compounds of the 1)ichl( )rodiphenvlt ri...

Adenovirus 2 (Ad2) inactivated by UV was used to transform LSH hamster embryo cells. Evaluation of transformed cell lines produced by Ad2 (prototype strain adenoid 6) or isolates of Ad2 obtained from children in Washington, D. C., or West Bengal, India, showed that 13 of 15 lines induced tumors when injected into newborn inbred LSH or randomly bred NIH ham sters [1o@cells/hamster with a median ...

H. Zehner, E. Westhof, W. Flossmann, and A. Müller, Formation of H-Addition Radicals in Adenine Deriva­ tives: Part I I ............................................................... U. F. Thomanek, F. Parak, and B. Wintergerst, The Active Center of Methemoglobin Hb(H20) Investi­ gated by Mössbauer and Susceptibility Experiments . U. P. Fringeli, The Structure of Lipids and Proteins Studied by...

Tay-Sachs disease is an autosomal recessive neurodegenerative disorder occurring due to impaired activity of β-hexosaminidase-A (EC 3.2.1.52), resulting from the mutation in HEXA gene. Very little is known about the molecular pathology of TSD in Indian children except for a few mutations identified by us. The present study is aimed to determine additional mutations leading to Tay-Sachs disease ...

``A na rch ic hand’ ’ is the te rm by w hich w e propo se to iden tify com p lex goa ldirec ted m ovem en ts o f a hand , w h ich a re pe rfo rm ed aga ins t the patien t’ s w ill, and that canno t b e volun tar ily inh ib ited . T h is phenom enon shou ld be d ifferen tia ted from the fee ling o f nonbelong ing o f a hand, know n in the lite ra ture since the repo rt of B rion and Jed inak (19...

tion from toxic oxygen species and detoxification of various xenobiotics (8, 9). The ability to modulate cellular GSH levels to probe the importance of this tripeptide in various drug or radiation interactions hascome from the elegant work of Meis ter and Griffith (10) and Williamson et a!. (11) who have introduced compounds that either inhibit or stimulate GSH synthesis. When GSH synthesis is ...

The Syrian golden hamster is a potentially useful model for studies of chemically induced pancreatic adenocarcinoma. In an effort to refine the model so its sensitivity to carcinogen can be enhanced such that dose and latent period are decreased and tumor yield increased, experiments were undertaken to induce pancreatic regeneration in the hamster. Random-bred male hamsters given eight daily i....