objective: in radiation treatment, the irradiation which is effective enough to control the tumors far exceeds normal-tissues tolerance. thus to avoid such unfavourable outcomes, some methods sensitizing the tumor cells to radiation are used. iododeoxyuridine (iudr) is a halogenated thymidine analogue that known to be effective as a radiosensitizer in human cancer therapy. improving the potenti...

Multileaf collimators (MLCs) are the prevailing tool for the realization of radiation fields in intensity modulated radiation therapy (IMRT). One step in the treatment planning is to determine a set of leaf positions realizing a certain intensity modulated radiation field. In this paper we suggest two extensions in the use of the MLC that lead to considerable savings in terms of monitor units, ...

introduction: radiotherapy is a common treatment modality for patients with head and neck malignancies. as the nose lies within the field of radiotherapy of the head and neck, the olfactory fibers and olfactory receptors may be affected by radiation. the aim of this study was to evaluate changes in olfactory threshold in patients with head and neck malignancies who have received radiation to th...

Introduction: Radiation-induced bystander effect (RIBE) is a well-known response associated with the induction of radiation effects in non-irradiated cells via signaling of hit ones. As this so-called phenomenon has been largely investigated in low dose levels, few studies focused on higher dose levels such as grid therapy. Grid therapy or spatially fractionated gri...

Background: The fundamental principles of internal targeted alpha therapy for cancer were established many decades ago.The high linear energy transfer (LET) of alpha radiation to the targeted cancer cellscauses double strand breaks in DNA. At the same time, the short range radiation spares adjacent normal tissues. This targeted approach complements conventional external beam radiotherapy and ch...

background: the presence of small intestine in the radiation field during pelvic cancers treatment causes an interruption in radiotherapy. a non-invasive method was developed to exclude small intestine during conventional radiotherapy. materials and methods: the incidence of the radiation therapy interruption is highly dependent upon the area of the small intestine included in the portals and i...

objective(s): radiation therapy for breast cancer can induce myocardial capillary injury and increase cardiovascular morbidity and mortality. a prospective cohort was conducted to study the prevalence of myocardial perfusion abnormalities following radiation therapy of left-sided breast cancer patients as compared to those with right–sided cancer. methods: to minimize potential confounding fact...

abstract prostate cancer is one of the life threatening disorders of male. although, over the last two decades, a high rate of overdiagnosis, and overtreatment has lowered the incidence rate of prostate cancer, the treatment or prevention strategies are not enough to control the high rate of disease related mortality. current medical treatment approaches include surgery, radiation therapy, chem...