Adult higher vertebrates have a limited potential to recover from spinal cord injury. Recently, evidence emerged that propriospinal connections are a promising target for intervention to improve functional regeneration. So far, no in vitro model exists that grants the possibility to examine functional recovery of propriospinal fibers. Therefore, a representative model that is based on two organ...

Total and regional allometric growth rates and termination sites of the spinal cord related to the respective vertebra were studied in 36 goat fetuses, from the Ahvaz slaughterhouse. These specimens were assigned to 3 groups, group 1 (CRL 10-20 cm), group 2 (CRL 21-30 cm), and group 3 (CRL 31-40 cm), each consisting of 6 male and 6 female fetuses. Observations in all 3 groups revealed that alth...

It is widely accepted that individual neurons in the central nervous system release only a single fast transmitter. The possibility of corelease of fast neurotransmitters was examined by making paired recordings from synaptically connected neurons in spinal cord slices. Unitary inhibitory postsynaptic currents generated at interneuron-motoneuron synapses consisted of a strychnine-sensitive, gly...

to date, various approaches have been used in attempt to treat spinal cord injury (sci) but there is no definite treatment for repair of the damaged tissue. it is well known that sci results in a loss of neural tissues and formation of cystic cavities that inhibit regeneration of axons. tissue engineering, in which cells, signals and scaffolds are combined, is one of the most promising areas of...

although spinal cord injury (sci) is one of the most common injuries after a road accident, there is no definite treatment for it. in this regard, nanotechnology has focused to retrieve damaged tissue function by designing of a biomaterial as a mimicking extracellular matrix to reduce inflammation, scar and lactate dehydrogenase, to fill the cyst and improve the graft integration, cell prolifer...

a 19-year-old man presented with a 5-year history of back pain radiating to the lower extremities and paresthesis of the toes during the last year. plain x-ray revealed a large cauliflower shaped exophytic mass at the level of t8, t9 and t10 vertebrae. computed tomography (ct) and magnetic resonance imaging (mri) showed an abnormal bony mass arising from the posterior arch of t9 with protrusion...

introduction spinal cord injury without radiological abnormality (sciwora) is a rare entity and usually involves the cervical spine. thoracic spine involvement is very rare due to the stability provided by the rib cage. the mechanisms of injury and pathophysiology are still debatable. case presentation we present a case of an adult male who had road traffic accident and presented with paraplegi...