Rosai-Dorfman disease (RDD) also known as sinus histiocytosis with massive lymphadenopathy is a rare disorder of histiocytes characterized histologically by intracellular engulfment lymphocytes. It may occur in any age group, but most commonly seen children and young adults. painless, bilateral cervical lymphadenopathy. In approximately one-third patients it can variety extranodal sites where h...

Rosai-Dorfman disease is a rare histiocytic proliferative disorder that commonly presents with a massive lymphadenopathy and a variety of constitutional symptoms. Severe hemolytic anemia is an infrequent complication of this disease. Although the etiology of the condition is unknown, infectious agents including viruses have been implicated. We describe a 2-year-old female child who presented wi...

synovial mesenchymal stem cells and hydroxyapatite-based artificial bone +Shimomura K; Moriguchi Y; Ando W; Nansai R; Susa T; Imade K; Mochiduki S; Fujie H; Kita K; Mae T; Nakata K; Shino K; Yoshikawa H; Nakamura N +Osaka University Graduate School of Medicine, Osaka, Japan, Kansai Rosai Hospital, Hyogo, Japan, Kogakuin University, Tokyo, Japan, Tokyo Metropolitan University, Tokyo, Japan, Osak...

A 15 year-old-male presented with concurrent sinonasal polyposis and anterior uveitis with cervical lymph node enlargement. Cervical lymph node biopsy confirmed Rosai-Dorfman disease. Though patient's eye symptoms did not respond well to topical corticosteroid treatment but he showed a remarkable regression in the size of nasal polyps and cervical lymph nodes after systemic corticosteroids. Int...

We share our experience with serial PET/CT imaging on a patient with extranodal Rosai-Dorfman disease (RDD) with hepatopancreatic involvement. RDD is a benign proliferative disorder of histiocytes mainly involving the lymph nodes. It typically presents with fever and painless cervical lymphadenopathy in young adults and less than half of RDS cases demonstrate extranodal involvement. RDD involve...

Rosai Dorfman disease (RDD) or sinus histiocytosis with massive lymphadenopathy (SHML) is a rare disorder that typically manifests as lymphadenopathy and systemic symptoms. The authors report a 45 year old lady who presented with nasal mass and generalised lymphadenopathy. Histopathological examination demonstrated lymphophagocytosis (emperipolesis) consistent with a diagnosis of RDD. The clini...

Sinus histiocytosis with massive lymphadenopathy also called as Rosai-Dorfman’s disease is a benign self limiting rare histiocytic disorder with very few case reports in Pakistani literature. This case report describes a young boy of nine years age who presented with progressive, asymptomatic bilateral cervical lymphadenopathy for eight months. Open cervical lymph node biopsy confirmed the diag...