objective(s) recent studies on human indicate that the introduction of therapeutic use of tolerogenic dendritic cell (dc) for chronic inflammatory conditions is imminent. for the purpose of defining cgrp potency in tolerogenic dc production, we investigated the phenotype and il-'2 production of dcs generated from the monocytes of rheumatoid arthritis (ra) patients in the presence of the ca...

introduction: rheumatoid arthritis (ra) is the most common autoimmune joint disease. osteoporosis is a well-known consequence of ra. objective: the aim of the present study was to determine the interrelationship between radiographic findings and bone mineral density (bmd) in patients with ra. methods: 70 patients with established ra (according to 1987 acr criteria) were included in a cross-sect...

background: this study aims to investigate the effect of antioxidants supplement on clinical outcomes and antioxidant parameters in rheumatoid arthritis (ra). methods: the pre‑post study was conducted on 40 female patients with ra in 12 weeks that taken daily one “selenplus” capsule contained 50 μg selenium, 8 mg zinc, 400 μg vitamin a, 125 mg vitamin c, and 40 mg vitamin e. about 5 ml venous b...

rheumatoid arthritis (ra) is a chronic autoimmune disease, which can lead to joint destruction and disability. pannus formation due to chronic synovitis is the hallmark of ra. oxidative stress as a consequence of immune cell activation and disease-modifying anti-rheumatic drugs can prevent inflammation and tissue destruction. silymarin, an antioxidant extract from silybum marianum, has been tra...

osteoporosis (op) is a frequent complication of rheumatoid arthritis (ra) and longitudinal studies have documented increased rate of bone loss in ra patients. to determine the frequency of low bone mass as well as the influence of disease duration and corticosteroid use on bone mass in patients with ra, 88 patients with ra and 112 age matched controls were studied. bone densitometry was perform...

Rheumatoid factors are antibodies directed against the Fc region of immunoglobulin G. First detected in patients with rheumatoid arthritis 70 years ago, they can also be found in patients with other autoimmune and nonautoimmune conditions, as well as in healthy subjects. Rheumatoid factors form part of the workup for the differential diagnosis of arthropathies. In clinical practice, it is recom...

INTRODUCTION Although cardiovascular morbidity and mortality are increased in rheumatoid arthritis, little is known about the burden of subclinical coronary atherosclerosis in these patients. METHODS Using computed tomography, coronary artery calcification was measured in 195 men and women with rheumatoid arthritis aged 45 to 84 years without clinical cardiovascular disease and compared with ...

OBJECTIVE To determine the mortality risk of Japanese patients with rheumatoid arthritis, taking into account lifestyle and physical factors, including comorbidity. METHODS 91 individuals with rheumatoid arthritis were identified during screening a cohort of 16 119 Japanese atomic bomb survivors in the period 1958 to 1966. These individuals and the remainder of the cohort were followed for mo...