نتایج جستجو برای: redox homeostasis

تعداد نتایج: 112752  

Journal: :Applied and environmental microbiology 2016
Natalie C Sadler Hans C Bernstein Matthew R Melnicki Moiz A Charania Eric A Hill Lindsey N Anderson Matthew E Monroe Richard D Smith Alexander S Beliaev Aaron T Wright

Photobiologically synthesized hydrogen (H2) gas is carbon neutral to produce and clean to combust, making it an ideal biofuel. Cyanothece sp. strain ATCC 51142 is a cyanobacterium capable of performing simultaneous oxygenic photosynthesis and H2 production, a highly perplexing phenomenon because H2 evolving enzymes are O2 sensitive. We employed a system-level in vivo chemoproteomic profiling ap...

2015
Kyle Sander Charlotte M. Wilson Miguel Rodriguez Dawn M. Klingeman Thomas Rydzak Brian H. Davison Steven D. Brown

BACKGROUND Clostridium thermocellum is a promising consolidated bioprocessing candidate organism capable of directly converting lignocellulosic biomass to ethanol. Current ethanol yields, productivities, and growth inhibitions are industrial deployment impediments for commodity fuel production by this bacterium. Redox imbalance under certain conditions and in engineered strains may contribute t...

Journal: :Molecular bioSystems 2015
D W Bak E Weerapana

The mitochondria are critical mediators of cellular redox homeostasis due to their role in the generation and dissipation of reactive oxygen/nitrogen species (ROS/RNS). Modulations in ROS/RNS levels in the mitochondria are often reflected through oxidation/nitrosation of highly redox-sensitive cysteine residues within this organelle. Oxidation/nitrosation of functional cysteines on mitochondria...

2013
Edward Avezov Benedict C.S. Cross Gabriele S. Kaminski Schierle Mikael Winters Heather P. Harding Eduardo Pinho Melo Clemens F. Kaminski David Ron

Interfering with disulfide bond formation impedes protein folding and promotes endoplasmic reticulum (ER) stress. Due to limitations in measurement techniques, the relationships of altered thiol redox and ER stress have been difficult to assess. We report that fluorescent lifetime measurements circumvented the crippling dimness of an ER-tuned fluorescent redox-responsive probe (roGFPiE), faithf...

Journal: :Organic & biomolecular chemistry 2009
Susanne Mecklenburg Saad Shaaban Lalla A Ba Torsten Burkholz Thomas Schneider Britta Diesel Alexandra K Kiemer Anne Röseler Katja Becker Jörg Reichrath Alexandra Stark Wolfgang Tilgen Muhammad Abbas Ludger A Wessjohann Florenz Sasse Claus Jacob

Various human illnesses, including several types of cancer and infectious diseases, are related to changes in the cellular redox homeostasis. During the last decade, several approaches have been explored which employ such disturbed redox balances for the benefit of therapy. Compounds able to modulate the intracellular redox state of cells have been developed, which effectively, yet also selecti...

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