A female with multiple dysmorphic features was found to have an unbalanced karyotype with duplication of the distal long arm of chromosome 17 and deletion of the terminal region of the short arm of chromosome 12. This was derived from a reciprocal translocation in the mother, 46,XX,t(12;17)(p13.3;q23). Clinical findings are presented and comparison with other reported cases of distal 17q duplic...

The objective of this study is to provide an alternative characterization of the optimal value function of a certain BlackScholes-type optimal stopping problem where the underlying stochastic process is a general random walk, i.e. the process constituted by partial sums of an IID sequence of random variables. Furthermore, the pasting principle of this optimal stopping problem is studied. JEL Cl...

MLL/GAS7, resulting from t(11;17)(q23;p13), has been reported in one case of treatment-related acute myeloid leukemia (AML). We present a de novo case of t(11;17)-positive pediatric acute lymphoblastic leukemia. Fluorescent in situ hybridization and reverse transcriptase polymerase chain reaction analyses revealed an MLL/GAS7 chimera identical to the one previously described in AML. The molecul...

Cleary Lauer, Donald H. Mahoney, D. Jeanette Pullen, Jonathan J. Shuster, C. Philip Steuber and Michael L. Stephen P. Hunger, Majilinde Z. Fall, Bruce M. Camitta, Andrew J. Carroll, Michael P. Link, Stephen J. Leukemias With a t(1;19)(q23;p13): A Pediatric Oncology Group Study Predictive of Treatment Outcome in Childhood Acute Lymphoblastic Chimeric Transcript Status at End of Consolidation Is ...

MLL is fused to ENL or ELL in acute leukemias that contain t(l1; 191(q23;p131. Although ENL and ELL localize to chromosome 19, bands p13.3 and p13.1, respectively, these breakpoints are not always readily distinguished by standard cytogenetics. We therefore used reversa transcriptasepolymerase chain reaction (RT-PCR) assays to analyze 26 cases of childhood acute leukemia containing t(l1; 19) to...

A patient with a partial deletion (q23 leads to qter) of the long arm of chromosome 11 presented with craniosynostosis and syndactyly. These characteristics, which have not been previously reported with 11q--, expand the phenotype of this syndrome and emphasise the need for chromosome analysis with banding techniques in multiple congenital anomaly syndromes, even if the patient could be classif...

We have analyzed a series of nine infant leukemias that carry a t(11;19)(q23;p13). They had the morphologic features of acute lymphoblastic leukemia (ALL) and expressed markers typical of B-cell progenitor ALL or pre-6 ALL; one coexpressed myeloid markers in addition to lymphoid markers (biphenotypic). Two probes (PIS4 and 98.40) subcloned from a yeast artificial chromosome (YAC) known to span ...

Mice with severe combined immunodeficiency (SCID) were injected intravenously with primary bone marrow blasts from 12 children with newly diagnosed t(4;ll)(q21;q23) acute lymphoblastic leukemia (ALL). Blasts from eight patients caused overt disseminated leukemia, whereas blasts from the other four patients produced occult leukemia that was detectable only by the polymerase chain reaction (PCR) ...