Pulsatile Drug delivery systems are gaining a lot of interest as they deliver the drug at the right site of action, at the right time and in the right amount, as per the pathophysiological needs of the diseases, resulting in increasing patient compliance. Pulsatile Drug Delivery systems are basically time-controlled drug delivery systems in which the system controls the lag time independent of ...

Cardiac related pulsatile signals can be detected in different parts of the human body, including the finger, ear lobe and forehead [1] by using near infrared (NIR) monitoring. These pulsatile signals are due to attenuation of light by the increase of arterial blood volume during systole in the cardiac cycle. Pulse oximetry exploits these pulsatile signals to calculate oxygen saturation (SpO2) ...

• Bruit or thrill suggestive of a traumatic arteriovenous fistula • Expanding or pulsatile hematoma • Pulsatile or severe hemorrhage • Pulse deficit—pulses may be normal in patients with nonocclusive injuries that require surgical repair, such as intimal flaps or pseudoaneurysms • Thorough vascular and esophageal evaluation is required, even with minor neck wounds, if any abnormalities are evid...

Pancreatic islets manage elevations in blood glucose level by secreting insulin into the bloodstream in a pulsatile manner. Pulsatile insulin secretion is governed by islet oscillations such as bursting electrical activity and periodic Ca2+ entry in β-cells. In this report, we demonstrate that although islet oscillations are lost by fixing a glucose stimulus at a high concentration, they may be...

When tinnitus is pulse-synchronous, a vascular etiology is suggested. We present a case of persistent and troublesome pulsatile tinnitus caused by a transverse-sigmoid sinus diverticulum that was endovascularly treated with stent-assisted coiling. A 39-yearold woman presented with a 4-year history of progressive pulsatile tinnitus involving the right ear. Slight pulsatile bruit was heard on the...

We have recently shown that ventricular unloading with an implantable left ventricular assist device (LVAD) leads to improved calcium handling and membrane integrity and redistribution of alpha adrenoreceptors (AARs) and betaadrenoreceptors (BARs). Here, we used fluorescence deconvolution microscopy to examine the effect of LVAD type (pulsatile vs non-pulsatile) on upregulation and redistributi...

BACKGROUND We aimed to investigate the effectiveness of two different forms of dry pulsatile cupping in patients with chronic low back pain (cLBP) compared to medication on demand only in a three-armed randomized trial. METHODS 110 cLBP patients were randomized to regular pulsatile cupping with 8 treatments plus paracetamol on demand (n = 37), minimal cupping with 8 treatments plus paracetamo...

BACKGROUND AND PURPOSE Aneurysm depiction with three-dimensional (3D) rotational angiography is influenced by investigator-defined parameters such as image acquisition and contrast agent injection and by the hemodynamic pattern in the parent artery and aneurysm. To assess the impact of the geometric configuration of parent artery and aneurysm on the 3D visualization of saccular aneurysms, we st...

In this case report, we present an 86-year old patient with an intercostal pseudoaneurysm after transaortic transcatheter aortic valve implantation (TAVI). This new technique of a transaortic approach is considered a possible alternative to the more usual transfemoral, trans-subclavian or transapical access site, mainly in patients with extensive peripheral arterial disease. A mini-thoracotomy ...

The dose-response curves of epinephrine given either IV or endotracheally (ET) were compared during resuscitation from electromechanical dissociation (EMD). Ten anesthetized dogs were subjected to a two-minute period of electrically induced ventricular fibrillation (VF) followed by defibrillation without CPR to produce EMD. Mechanical CPR was followed by injection of either ET or IV epinephrine...