BACKGROUND It is unknown whether prodromal services improve outcomes in those who go on to develop psychosis, and whether these patients are demographically different from the overall first-episode population. AIMS To compare sociodemographic features, duration of untreated psychosis, hospital admission and frequency of compulsory treatment in the first year after the onset of psychosis in pa...

BACKGROUND In schizophrenia research, early detection in the initial prodrome before first psychotic episodes is a major topic. Therefore, the prognostic accuracy of initial prodromal symptoms was examined prospectively. METHODS The study sample was composed of patients referred to outpatient departments of German psychiatric university departments, because of diagnostic problems, between 198...

According to Sydenham (1717), the rash of measles appears on the fourth, or sometimes the fifth, day of the illness. This has remained the standard teaching of most of the authorities on infectious diseases and paediatrics (e.g. Sheldon, 1948; Banks, 1949; Harries and Mitman, 1951; Top, 1955). However, Panum (1847), in his classic report of a measles epidemic, states that although the prodromal...

Early treatment of recrudescent herpes labialis over the symptomatic area has been claimed to inhibit the clinical signs of recrudescent herpes labialis. Electronic infrared thermography can both recognise the prodromal phase and identify the area requiring drug therapy. Our objective was to use infrared thermography to identify prodromal herpes and follow the response to topical acyclovir crea...

Huntington's disease is an autosomal dominant brain disease. Although conceptualized as a neurodegenerative disease of the striatum, a growing number of studies challenge this classic concept of Huntington's disease aetiology. Intracranial volume is the tissue and fluid within the calvarium and is a representation of the maximal brain growth obtained during development. The current study report...

Schizophrenia can develop in junior and senior high school students. Correct identification of schizophrenia symptoms is an important factor in subsequent healthcare. The present study conducted a multifaceted evaluation of factors associated with an absence of effect of an education program for improving knowledge of schizophrenia among parents of Japanese junior and senior high school student...

background: enhanced external counterpulsation (eecp) is a noninvasive technique used for patients with refractory angina pectoris. there are controversial data on the effectiveness of eecp in improving patients with refractory stable angina. the aim of the present study was to evaluate the effectiveness and safety of eecp for the treatment of patients with refractory angina pectoris. methods: ...

coronary  atherosclerotic  disease  is  one  of  the  most  endangering  health  disorder worldwide. this study was designed to investigate the correlation between hla-drβ1 alleles and circulating th1/th2 type cytokines in coronary atherosclerosis. by elisa, th1/th2 type cytokines were determined in serum samples of 31 subjects with unstable angina, 27 subjects with chronic stable angina and 24...

Chemokine (C-C motif) receptor 2 (CCR2)-signaling can mediate accumulation of microglia at sites affected by neuroinflammation. CCR2 and its main ligand CCL2 (MCP-1) might also be involved in the altered metabolism of beta-amyloid (Aβ) underlying Alzheimer's disease (AD). We therefore measured the levels of CCL2 and three other CCR2 ligands, i.e. CCL11 (eotaxin), CCL13 (MCP-4) and CCL26 (eotaxi...