Talinolol is a beta1-selective adreno receptor antagonist well known for its Cardio protective and antihypertensive activity. beta blocker. In biopharmaceutical classification system the drugs which come under class II are characterized by more membrane permeability, less dissolution rate. poor aqueous solubility drug leads to bioavailability. So, aimed of this study was develop immediate relea...

The present study investigates the possibility of using poloxamers as solubility and dissolution rate enhancing agents of poorly water soluble bioactive constituent patchouli alcohol (PA) that can be used for the preparation of immediate release pellets formulation. Two commercially available grades poloxamer 188 (P 188) and poloxamer 407 (P 407) were selected, and solid dispersions (SDs) conta...

In this paper, the optimal composition of a paeonol temperature-sensitive in situ gel composed of poloxamer 407 (P407) was determined, and a preliminary study of its effect on allergic rhinitis was performed. The optimal composition of the paeonol temperature-sensitive in situ gel included 2% paeonol inclusion, 22% P407, 2% poloxamer 188 (P188) and 2% PEG6000, as assessed by thermodynamic and r...

Result: Specific IgE antibodies were detected in 29/42 (69%) of all the subjects. The sensitization rate was highest for pollen while results for other allergen groups are as follows: pollen 86/127 (66.9%), animal dander 29/127 (22.8%), HDM 11/127 (8.6%) and moulds 2/127 (1.6%). Among allergenic pollen, mixed grasses were the most common cause of sensitization 14/127 (11.0%). Sensitization rate...

glibenclamide (glib) is a poorly soluble drug with formulation-dependent bioavailability. therefore, we attempted in this study to improve glib dissolution rate by preparing drug solid dispersions by solvent evaporation (se) and supercritical fluid solvent-antisolvent techniques (scf-sas). a d-optimal mixture design was used to investigate the effects of different ratios of hpmc e5 (50-100%), p...

Pneumatic extrusion-based bioprinting is a recent and interesting technology that is very useful for biomedical applications. However, many process parameters in the bioprinter need to be fully understood in order to print at an adequate resolution. In this paper, a simple yet accurate mathematical model to predict the printed width of a continuous hydrogel line is proposed, in which the resolu...