Controversy persists regarding the role of histopathology in the distinction between essential thrombocythemia (ET) and early-prefibrotic primary myelofi-brosis (PMF) presenting with thrombocythemia. To investigate the impact and reproducibility of bone marrow (BM) morphology according to the World Health Organization classification, 295 patients with the presumptive clinical diagnosis of eithe...

Coal workers' pneumoconiosis (CWP) is characterized as a chronic inflammation of the lung associated with activation of macrophages and endothelial cells in the lung. The aim of the present study was to compare the levels of serum interleukin-8 (IL-8), macrophage inflammatory protein-1α (MIP-α), and intercellular adhesion molecule-1 (ICAM-1) as biomarkers for progressive massive fibrosis (PMF) ...

Chemical communication via chemosensory signaling is an essential process for promoting and modifying reproductive behavior in many species. During courtship in plethodontid salamanders, males deliver a mixture of non-volatile proteinaceous pheromones that activate chemosensory neurons in the vomeronasal epithelium (VNE) and increase female receptivity. One component of this mixture, Plethodont...

Enzymes expressed in response to vinyl chloride, ethene, and epoxyethane by Nocardioides sp. strain JS614 were identified by using a peptide mass fingerprinting (PMF) approach. PMF provided insight concerning vinyl chloride biodegradation in strain JS614 and extends the use of matrix-assisted laser desorption-ionization time of flight mass spectrometry as a tool to enhance characterization of b...

We consider here the class of probability mass-function (PMF) based detectors of least significant bit (LSB) embedded steganography. That is, in this paper we investigate the use of frequency counts of pixel intensities as a statistic for tests detecting the presence of hidden messages. We focus on LSB replacement (though we briefly consider LSB matching) embedding as it is a simple technique w...

To update oncologists on pathogenesis, contemporary diagnosis, risk stratification, and treatment strategies in BCR-ABL1-negative myeloproliferative neoplasms, including polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). Recent literature was reviewed and interpreted in the context of the authors' own experience and expertise. Pathogenetic mechanisms in PV,...

Growth differentiation factor 15 (GDF15) is a pleiotropic cytokine that belongs to the transforming growth factor-β superfamily. Elevated serum concentrations of this cytokine have been reported in patients with various malignancies. To assess the potential roles of GDF15 in hematologic malignancies, we measured its serum levels in patients with these diseases. We found that serum GDF15 levels ...

Most models will attempt to extract losses (interception, surface storage, infiltration) from the input and build a runoff hydrograph using empirical curves or by routing the excess water. Even the simplest models generally involve many parameters to describe these processes. Some parameters are estimated from published values, and others are set based on past practice and calibration of the mo...

A fiber twist sensor using a Sagnac interferometer incorporating tapered polarization-maintaining (PMF) is proposed. The transmission properties of the are investigated both theoretically and experimentally. Given optoelastic effect, which depends on geometry, modal group birefringences PMF can be controlled by applying different angles. spectral wavelength shifts, free ranges, losses original,...