The aim of this study is to compare two different productions of Albanian and Canadian B-complex multivitamin tablets on the Albanian pharmaceutical market through various ‘in vitro’ pharmacopeias tests and argue about the regulatory legislative framework of drugstore sale of these products. Identification, weight uniformity, hardness and disintegration tests are carried out for the specific vi...

In this study we have reported a new, fast and extraction free spectrophotometric procedure for the assessment of caroverine in pharmaceutical raw and tablet dosage forms. In the reported visible spectrophotometric procedure tungstate in Folin-Ciocalteu phenol reagent is reduced in alkaline medium and produces the blue colored chromogen that shows Λmax at 740nm with the calibration range of 2-2...

The present article gives an introduction and general overview on process validation of pharmaceutical manufacturing process especially tablet manufacturing process. The principal objective of dosage form design is to achieve a predictable therapeutic response to a drug included in a formulation which is capable of large scale manufacture with reproducible product quality. Solid dosage forms in...

One of the common methods used in pharmaceutical industry to coat tablets is add a thin polymer-based coating tablet or granule that contains medicament. Solid dosage forms, such as capsule pill, are frequently used. Controlled release one primary causes. The amount on surface has significant impact how effective oral form is.
 Tablets typically coated by spraying specialised solutions ove...

The pharmaceutical industry is one of the most productive and competitive industries in the world. Many of the large pharmaceutical companies (often termed ‘Big Pharma’) base their primary operations in the USA and maintain extensive facilities in countries around the world. Pharmaceutical research is, therefore, an activity of global importance. The intensely competitive and global nature of B...

Background Tablet splitting can provide dose flexibility and cost savings; however, pharmaceutical representatives typically discourage the practice. Aim To identify summarise all published concerns related to tablet present experimental evidence that investigates those concerns. Design & setting Systematic review qualitative synthesis of tablet-splitting evidence...

In modern age of revolution and development in drug delivery for better clinical effects conventional dosages form have still a strong grip most popular all kinds medicinal preparation intended oral use. To satisfy the need growing market tablets incorporated modernization producing some advanced tablet types. Modified release formulations including, layered such as +--lay tablet, Bi-layered Me...

BACKGROUND Prescription of fragmented tablets is useful for individualisation of dose but includes several drawbacks. Although without score lines, the antipsychotic drug quetiapine was in 2011 the most often prescribed 1/2 tablet in discharge prescriptions at the University Hospital in Basel (USB, 671 beds). We aimed at analysing the prescription patterns of split tablets in general and of que...

Many kinds of rapidly disintegrating or oral disintegrating tablets (RDT) have been developed to improve the ease of tablet administration, especially for elderly and pediatric patients. In these cases, knowledge regarding disintegration behavior appears important with respect to the development of such a novel tablet. Ordinary disintegration testing, such as the Japanese Pharmacopoeia (JP) met...

1. Yong CS, Jung JH, Rhee JD, Kook KC, Choi HG. Physicochemical characterization and evaluation of buccal adhesive tablets containing omeprazole. Drug Develop Ind Pharm 2001;27:447-55. 2. Martindale-The complete drug reference. In: Sweetman SC, editor. London: Pharmaceutical Press; 2005. 3. Clarke’s Analysis of Drugs and Poisons. In: Moffat AC, Osselton MD, Widdop B, editors. London: Pharmaceut...