نتایج جستجو برای: pentylenetetrazol anticonvulsion test

تعداد نتایج: 812568  

Journal: :Seizure 2004
Graeme J Sills Elaine Butler George G Thompson Martin J Brodie

There is emerging evidence to support the efficacy of some antiepileptic drug (AED) combinations in refractory epilepsy. Definitive clinical studies are, however, difficult to perform. Experimental seizure models can be employed to identify potentially useful combinations for subsequent clinical evaluation. We have investigated the anticonvulsant effects of topiramate (TPM) in combination with ...

Journal: :Proceedings for Annual Meeting of The Japanese Pharmacological Society 2020

2011
Hamid Reza Sadeghnia Sahar Darbarpanah Seyed Mahmood Hosseini

Objective: Antiepileptic drugs (AEDs) that are usually used for treatment of epilepsy have substantial side effects and about 30% of patients continue to have seizures with current AEDs therapy. Some herbs which traditionally used in the management of seizures of many rural areas of the developing countries have shown anticonvulsant activity in modern pharmacological bioassays. The aim of the p...

2012
Fariba Karimzadeh Mahmoud Hosseini Diana Mangeng Hassan Alavi Gholam Reza Hassanzadeh Mohamad Bayat Maryam Jafarian Hadi Kazemi Ali Gorji

BACKGROUND Essential oil of Pimpinella anisum L. Apiaceae (anise oil) has been widely used in traditional Persian medicine to treat a variety of diseases, including some neurological disorders. This study was aimed to test the possible anti-seizure and anti-hypoxia effects of anise oil. METHODS The effects of different concentrations of anise oil were tested on seizure attacks induced by pent...

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