Background Among all pediatric cancers acute lymphoblastic leukemia (ALL) is highly prevalent, butthe overall cost of ALL management is not well-known, there is a need to assess the Berlin-Frankfurt-Munster (BFM) protocol commonly used in ALL management in Iran. So, the aim of this study was to estimate direct and indirect costs of ALL treatment among children based on the ALL-BFM protocol from...

UNLABELLED With advances in medical care, the majority of children with sickle cell disease are surviving to adulthood. Patients, families, and providers now face the need for this growing population to move from pediatric- to adult-focused care. In order to facilitate a successful transfer to adult health care, and prepare young adults for greater independence, it is recommended that all pedia...

OBJECTIVE Pediatric dysphagia occurs in 500,000 children each year; however, there is not a common tool to assess these children. Our aim was to identify validated patient- or parent-reported outcome assessment tools evaluating pediatric dysphagia. DATA SOURCES Scopus, EMBASE, PubMed, Cochrane Library, and CINAHL electronic databases (all indexed years through August 2014). REVIEW METHODS I...

Pediatric liver tumors account for approximately 1% of all liver tumors and up to 2% of all pediatric malignancies [1,2]. While the overall incidence of liver tumors is rare, the liver remains the third most common organ of origin for solid abdominal tumors in the pediatric population [3]. The majority of pediatric liver tumors, both benign and malignant, occur (almost) exclusively in children....

background: acute drug poisoning remains an important public health problem and represents the second most frequent accidental disease in children. in this study, we identified epidemiological and clinical features of children admitted for acute drug poisoning and related factors associated with suicidal poisoning. methods: we conducted a retrospective study in the department of pediatrics, the...

amyloidosis of the upper aerodigestive tract is rare in the pediatric age group. we present two cases of pediatric laryngeal amyloidosis. both of them had hoarseness as the presenting symptom. diagnostic evaluation included flexible nasopharyngoscopy, rigid laryngoscopy, biopsy, computed tomography scan and laboratory tests. the results of congo red staining of the specimen were characteristic ...

background: selecting the best medication for upper gi endoscopy in children is a challenging issue. the goal of this study was to compare the effects of oral and intravenous midazolam for upper gastrointestinal endoscopy (ugie) on children. methods: in this randomized clinical trial study conducted in amirkola children's hospital, 110 children were randomly assigned to oral or intravenous...

There are many causes of gastrointestinal bleeding (GIB) in children, and this condition is not rare, having a reported incidence of 6.4%. Causes vary with age, but show considerable overlap; moreover, while many of the causes in the pediatric population are similar to those in adults, some lesions are unique to children. The diagnostic approach for pediatric GIB includes definition of the etio...

Histone modification enzymes regulate gene expression by altering the accessibility of promoters to transcription factors. We sought to determine whether the genes encoding histone modification enzymes are dysregulated in pediatric acute lymphoblastic leukemia (ALL). A real-time PCR array was designed, tested and used to profile the expression of 85 genes encoding histone modification enzymes i...