نتایج جستجو برای: null genotype

تعداد نتایج: 136240  

2017
Daiana B. Leonardi Mercedes Abbate María C. Riccheri Myriam Nuñez Graciela Alfonso Geraldine Gueron Adriana De Siervi Elba Vazquez Javier Cotignola

The inclusion of genotype at Acute Lymphoblastic Leukemia (ALL) diagnosis as a genetic predictor of disease outcome is under constant study. However, results are inconclusive and seem to be population specific. We analyzed the predictive value of germline polymorphisms for childhood ALL relapse and survival. We retrospectively recruited 140 Argentine patients with de novo ALL. Genotypes were an...

Journal: :Asian Pacific journal of cancer prevention : APJCP 2013
Zheng-Hui Hu Yi-Wei Lin Xin Xu Hong Chen Ye-Qing Mao Jian Wu Yi Zhu Xiang-Lai Xu Li-Ping Xie

BACKGROUND Many studies have investigated associations between the glutathione S-transferase M1 (GSTM1) null polymorphism and risk of prostate cancer, but the impact of GSTM1 in people who live in Asian countries is still unclear owing to inconsistencies across results. METHODS We searched the PubMed, Web of Science, Scopus, Ovid and CNKI databases for studies of associations between the GSTM...

2005
A. Demir S. Altin I. Demir V. Koksal U. Cetincelik S. I. Dincer

BACKGROUND: Previous studies have suggested that Glutathione S-transferase (GST) genotypes may play a role in determining susceptibility to lung cancer, though the data are often conflicting. In different ethnic groups variations in null allele frequency has been observed. AIMS: We aimed to evaluate whether genetic polymorphisms of Glutathione S-transferase theta (GSTT1) influence individual su...

Journal: :Genetics and molecular research : GMR 2015
A de P R Júnior G M Dos Reis K S F E Silva D A Rodrigues M C S Gomes J V M Martins I R da Costa G A Freitas K K V O Moura

The first reports about pterygium date back to Hippocrates, and this disease still threatens vision health around the world. Pterygium is a formation of fibrous tissue consisting of highly vascularized epithelial and subepithelial tissue that grows excessively and with an abnormal shape on the cornea. Many physical and biological factors are associated with the pathogenesis of pterygium, includ...

Journal: :Journal of occupational and environmental medicine 2004
Jiin-Chyuan Luo Tsun-Jen Cheng Hsen-Wen Kuo Ming J W Chang

Epichlorohydrin (1-chloro-2,3,-epoxypropane; ECH) is a strong irritant of the eyes, respiratory tract, and skin. Because the toxic effect of various chemicals can be modified by metabolic traits, in this study, we also investigated the influence of the glutathione S-transferase (GSTM1) and (GSTT1) genes on the toxic effect of ECH. In the GSTM1 null genotype workers, there is a dose-response of ...

2012
Seyed Morteza Seifati Kazem Parivar Abbas Aflatoonian Razieh Dehghani Firouzabadi Mohammad Hasan Sheikhha

BACKGROUND Endometriosis is one of the most common gynecologic disorders. It is a complex trait and both genetic and environmental factors have been implicated in its pathogenesis. There is growing evidence indicating that exposure to environmental contaminants is a risk factor for endometriosis. Glutathione-S-Transferase M1 (GSTM1) is one of the genes involved in detoxification of endogenous a...

2006
Nicole M. Probst-Hensch Robert W. Haile Sue Ann Ingles Matthew P. Longnecker Chun-Ya Han Bruce K. Lin David B. Lee Gordon T. Sakamoto Harold D. Frank Eric R. Lee Henry J. Lin

Polymorphic W-acetyltransferase (NAT2), an enzyme present in the colon, may affect incidence of colon cancer. Individuals with NAT2 fast acetylator genotypes may have higher colon cancer risks due to faster conversion of certain carcinogens to mutagens. We determined NAT2 genotypes in 447 subjects with distal colon adenomas and in 487 controls. No significant increase in adenoma prevalence amon...

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2002
Elaine Cristina Morari Janaína Luísa Pereira Leite Fabiana Granja Lígia Vera Montalli da Assumpção Laura Sterian Ward

Susceptibility to chemical carcinogens plays an important role in the development of most cancers. Several polymorphisms of human drug-metabolizing enzymes influence this individual susceptibility. The genes that encode the isoenzymes of the glutathione s-transferase (GST) system present a polymorphic inheritance. The GST mu 1 (GSTM1) and GST theta 1 (GSTT1) genes have a null allele variant in ...

2015
Sitakan Natphopsuk Wannapa Settheetham-Ishida Dariwan Settheetham Takafumi Ishida

Glutathione S-transferases (GSTs) belong to a group of the phase II enzymes, which play roles in the detoxification of exogenous substrates (Schnakenberg et al 2000, Sanyal et al 2004). Among a variety of GST genes, an allele with a deletion of the whole GSTM1 gene (GSTM1Δ) was identified (Duell et al., 2002). Homozygous for the GSTM1Δ known as GSTM1-null resulting in the lack of enzyme activit...

Journal: :Genetics and molecular research : GMR 2015
D A Rodrigues I R Costa J V M Martins K S F E Silva K K V O Moura

Genetic polymorphisms are defined as changes within the DNA sequences of genes that have frequencies in the population higher than 1%. The glutathione S-transferases play an important role in the cellular detoxification systems involved in oxidative stress that can lead to accumulation of reactive oxygen species. Epidemiological studies have suggested that individuals with homozygous deletion o...

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